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Maternal serum concentrations of the chemokine CXCL10/IP-10 are elevated in acute pyelonephritis during pregnancy

Cited 18 time in Web of Science Cited 18 time in Scopus
Authors
Gotsch, Francesca; Romero, Roberto; Espinoza, Jimmy; Kusanovic, Juan Pedro; Mazaki-Tovi, Shali; Erez, Offer; Than, Nandor Gabor; Edwin, Samuel; Mazor, Moshe; Yoon, Bo Hyan; Hassan, Sonia S
Issue Date
2007-09-01
Publisher
Taylor & Francis
Citation
J Matern Fetal Neonatal Med. 2007 Oct;20(10):735-44.
Keywords
Bacteremia/bloodBacteriuria/complicationsBiological MarkersCase-Control StudiesChemokine CXCL10/*bloodCross-Sectional StudiesFemaleHumansPregnancyPregnancy Complications, Infectious/*blood/immunologyPyelonephritis/*blood/complications/immunology
Abstract
OBJECTIVE: Acute pyelonephritis is one of the most frequent medical complications of pregnancy, as well as a common cause of antepartum hospitalization. Interferon (IFN)-gamma inducible protein, CXCL10/IP-10, is a member of the CXC chemokine family with pro-inflammatory and anti-angiogenic properties. The purpose of this study was to determine whether maternal serum concentrations of CXCL10/IP-10 change in patients with acute pyelonephritis during pregnancy. STUDY DESIGN: This cross-sectional study was conducted to determine the difference in maternal serum concentrations of CXCL10/IP-10 in pregnant women with acute pyelonephritis (N = 41) and normal pregnant women (N = 89). Pyelonephritis was defined in the presence of a positive urine culture, fever, and maternal clinical signs; blood cultures were performed in 36 cases. Maternal serum concentrations of CXCL10/IP-10 were measured by a sensitive immunoassay. Non-parametric statistics were used for analysis. RESULTS: (1) The median serum concentration of CXCL10/IP-10 in pregnant patients with pyelonephritis was significantly higher than in normal pregnant women (median 318.5 pg/mL, range 78.8-2459.2 vs. median 116.1 pg/mL, range 40.7-1314.3, respectively; p < 0.001); (2) maternal median serum concentrations of CXCL10/IP-10 did not differ significantly among patients with acute pyelonephritis with and without bacteremia (positive blood cultures: median 362.6 pg/mL, range 100.2-2459.2 vs. negative blood cultures: median 298.9 pg/mL, range 108.5-1148.7, respectively; p = 0.3). CONCLUSIONS: Pyelonephritis in pregnant women is associated with an increased maternal serum concentration of the chemokine CXCL10/IP-10.
ISSN
1476-7058 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17763275

http://hdl.handle.net/10371/15632
DOI
https://doi.org/10.1080/14767050701511650
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College of Medicine/School of Medicine (의과대학/대학원)Obstetrics & Gynecology (산부인과전공)Journal Papers (저널논문_산부인과학전공)
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