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A preliminary study on reduced dose (33 or 25 microg) gonadotropin-releasing hormone agonist long protocol for multifollicular ovarian stimulation in patients with high basal serum follicle-stimulating hormone levels undergoing in vitro fertilization-embryo transfer

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dc.contributor.authorKu, Seung-Yup-
dc.contributor.authorChoi, Young Sik-
dc.contributor.authorJee, Byung Chul-
dc.contributor.authorSuh, Chang Suk-
dc.contributor.authorChoi, Young Min-
dc.contributor.authorKim, Jung Gu-
dc.contributor.authorMoon, Shin Yong-
dc.contributor.authorKim, Seok Hyun-
dc.date.accessioned2009-11-26T02:27:56Z-
dc.date.available2009-11-26T02:27:56Z-
dc.date.issued2005-12-01-
dc.identifier.citationGynecol Endocrinol. 2005 Oct;21(4):227-31.en
dc.identifier.issn0951-3590 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16316845-
dc.identifier.urihttps://hdl.handle.net/10371/15634-
dc.description.abstractThe aim of the present study was to evaluate the clinical efficacy of half-dose (50 mug) and further reduced dose (33 or 25 mug) gonadotropin-releasing hormone agonist (GnRH-a; triptorelin) long protocols for multifollicular ovarian stimulation (MFOS) for patients with high basal serum follicle-stimulating hormone (FSH) level undergoing in vitro fertilization and embryo transfer (IVF-ET). One hundred and two IVF-ET cycles performed in 84 infertile patients with high basal serum FSH (>10.0 mIU/ml) were included in this retrospective study. Study subjects were assigned to two groups: continuous half-dose GnRH-a long protocol (group A, n = 63) vs. further reduced dose GnRH-a long protocol (group B, n = 39) from half-dose at the start of GnRH-a to one-third or one-quarter dose after pituitary downregulation. Exogenous FSH or human menopausal gonadotropin was administered for MFOS in step-down mode, four or fewer embryos were transferred, and the outcomes of MFOS were compared between the two groups. Serum estradiol (E(2)) level on the day of human chorionic gonadotropin administration was significantly higher in group B (mean +/- standard deviation (SD): 1318.3 +/- 1120.4 vs. 2054.9 +/- 1773.5 pg/ml, p = 0.015). The number of transferable and good-quality embryos was also significantly higher in group B (mean +/- SD: 2.9 +/- 1.7 vs. 3.7 +/- 2.0, p = 0.027; 1.8 +/- 1.4 vs. 2.7 +/- 2.0, p = 0.020). No statistically significant difference in the outcomes was observed with respect to the dose of gonadotropins administered, the number of oocytes retrieved or the clinical pregnancy rate. In conclusion, GnRH-a long protocol with a reduced dose, tapered from the starting half-dose to a third or a quarter of the normal dose after pituitary suppression, may be beneficial for MFOS in IVF-ET patients with a high basal serum FSH level. A further prospective randomized controlled study on a larger scale is needed to confirm these findings.en
dc.language.isoen-
dc.publisherTaylor & Francisen
dc.subjectAdulten
dc.subjectChorionic Gonadotropin/administration & dosageen
dc.subjectDose-Response Relationship, Drugen
dc.subjectEstradiol/blooden
dc.subjectFemaleen
dc.subjectFollicle Stimulating Hormone/administration & dosage/*blooden
dc.subjectHumansen
dc.subjectInfertility, Female/therapyen
dc.subjectMenotropins/administration & dosageen
dc.subjectOvarian Follicle/physiologyen
dc.subjectOvulation Induction/*methodsen
dc.subjectRetrospective Studiesen
dc.subjectTriptorelin/*administration & dosageen
dc.subjectEmbryo Transfer-
dc.subjectFertilization in Vitro-
dc.titleA preliminary study on reduced dose (33 or 25 microg) gonadotropin-releasing hormone agonist long protocol for multifollicular ovarian stimulation in patients with high basal serum follicle-stimulating hormone levels undergoing in vitro fertilization-embryo transferen
dc.typeArticleen
dc.contributor.AlternativeAuthor구승엽-
dc.contributor.AlternativeAuthor최영식-
dc.contributor.AlternativeAuthor지병철-
dc.contributor.AlternativeAuthor서창석-
dc.contributor.AlternativeAuthor최영민-
dc.contributor.AlternativeAuthor김정구-
dc.contributor.AlternativeAuthor문신용-
dc.contributor.AlternativeAuthor김석현-
dc.identifier.doi10.1080/09513590500282125-
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