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Proliferation of activated CD1d-restricted NKT cells is down-modulated by lymphocyte activation gene-3 signaling via cell cycle arrest in S phase

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Authors
Byun, Hyun-Jung; Jung, Woon-Won; Lee, Dong-Sup; Kim, Sanghee; Kim, Sang Joon; Park, Chung-Gyu; Chung, Hee Yong; Chun, Taehoon
Issue Date
2006-12-19
Publisher
Elsevier
Citation
Cell Biol Int. 2007 Mar;31(3):257-62. Epub 2006 Nov 14.
Keywords
AnimalsAntigens, CD/*immunologyAntigens, CD1/*immunologyCell ProliferationDown-RegulationGene Expression Regulation/*immunologyImmunologic FactorsKiller Cells, Natural/*cytology/*immunologyLymphocyte Activation/*geneticsMiceS Phase/geneticsSignal Transduction/*immunologyTransduction, Genetic
Abstract
Upon antigenic stimulation, CD1d-restricted NKT cells quickly secrete large amounts of cytokines. This prompt response demonstrates that CD1d-restricted NKT cells may potentially prove to be useful therapeutic agents for the treatment of many diseases. Despite the clinical importance of CD1d-restricted NKT cells, the regulating mechanisms of this unique T cell population remain to be defined. We found murine LAG-3 is inducible on CD1d-restricted NKT cells as the result of a variety of stimulants such as concanavalin A (con A) and anti-CD3. Also, antigen-specific CD1d stimulation can elicit LAG-3 in CD1d-restricted NKT cells. Moreover, ectopic LAG-3 expression on CD1d-restricted NKT cells results in cell cycle arrest in the S phase. These results show that LAG-3 signaling on activated CD1d-restricted NKT cells may down-modulate NKT cell proliferation.
ISSN
1065-6995 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17175182

http://hdl.handle.net/10371/15696
DOI
https://doi.org/10.1016/j.cellbi.2006.11.002
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College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
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