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Proliferation of activated CD1d-restricted NKT cells is down-modulated by lymphocyte activation gene-3 signaling via cell cycle arrest in S phase
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Byun, Hyun-Jung | - |
dc.contributor.author | Jung, Woon-Won | - |
dc.contributor.author | Lee, Dong-Sup | - |
dc.contributor.author | Kim, Sanghee | - |
dc.contributor.author | Kim, Sang Joon | - |
dc.contributor.author | Park, Chung-Gyu | - |
dc.contributor.author | Chung, Hee Yong | - |
dc.contributor.author | Chun, Taehoon | - |
dc.date.accessioned | 2009-11-26T02:52:29Z | - |
dc.date.available | 2009-11-26T02:52:29Z | - |
dc.date.issued | 2006-12-19 | - |
dc.identifier.citation | Cell Biol Int. 2007 Mar;31(3):257-62. Epub 2006 Nov 14. | en |
dc.identifier.issn | 1065-6995 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17175182 | - |
dc.identifier.uri | https://hdl.handle.net/10371/15696 | - |
dc.description.abstract | Upon antigenic stimulation, CD1d-restricted NKT cells quickly secrete large amounts of cytokines. This prompt response demonstrates that CD1d-restricted NKT cells may potentially prove to be useful therapeutic agents for the treatment of many diseases. Despite the clinical importance of CD1d-restricted NKT cells, the regulating mechanisms of this unique T cell population remain to be defined. We found murine LAG-3 is inducible on CD1d-restricted NKT cells as the result of a variety of stimulants such as concanavalin A (con A) and anti-CD3. Also, antigen-specific CD1d stimulation can elicit LAG-3 in CD1d-restricted NKT cells. Moreover, ectopic LAG-3 expression on CD1d-restricted NKT cells results in cell cycle arrest in the S phase. These results show that LAG-3 signaling on activated CD1d-restricted NKT cells may down-modulate NKT cell proliferation. | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | Animals | en |
dc.subject | Antigens, CD/*immunology | en |
dc.subject | Antigens, CD1/*immunology | en |
dc.subject | Cell Proliferation | en |
dc.subject | Down-Regulation | en |
dc.subject | Gene Expression Regulation/*immunology | en |
dc.subject | Immunologic Factors | en |
dc.subject | Killer Cells, Natural/*cytology/*immunology | en |
dc.subject | Lymphocyte Activation/*genetics | en |
dc.subject | Mice | en |
dc.subject | S Phase/genetics | en |
dc.subject | Signal Transduction/*immunology | en |
dc.subject | Transduction, Genetic | en |
dc.title | Proliferation of activated CD1d-restricted NKT cells is down-modulated by lymphocyte activation gene-3 signaling via cell cycle arrest in S phase | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 변현정 | - |
dc.contributor.AlternativeAuthor | 정운원 | - |
dc.contributor.AlternativeAuthor | 이동섭 | - |
dc.contributor.AlternativeAuthor | 김상희 | - |
dc.contributor.AlternativeAuthor | 김상준 | - |
dc.contributor.AlternativeAuthor | 박정규 | - |
dc.contributor.AlternativeAuthor | 정희용 | - |
dc.contributor.AlternativeAuthor | 전태훈 | - |
dc.identifier.doi | 10.1016/j.cellbi.2006.11.002 | - |
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