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Effect of mechanical strain on human limbal epithelial cells in vitro

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Authors
Oh, Joo Youn; Jung, Kyoung Ah; Kim, Mee Kum; Wee, Won Ryang; Lee, Jin Hak
Issue Date
2006-12-16
Publisher
Taylor & Francis
Citation
Curr Eye Res. 2006 Dec;31(12):1015-20.
Keywords
Blotting, WesternCell Adhesion Molecules/*biosynthesisCell ShapeCells, CulturedEnzyme-Linked Immunosorbent AssayEpithelial Cells/*physiologyExtracellular Matrix/*metabolismFibronectins/*biosynthesisHumansLimbus Corneae/*cytologyStress, Mechanical
Abstract
PURPOSE: To investigate the effects of the mechanical cyclic strain on the extracellular matrix (ECM) production by cultivated human limbal epithelial cells (HLECs) in vitro. METHODS: HLECs were repetitively stretched and relaxed by 20% of their original length. Morphology of HLECs was observed, and concentrations of fibronectin and laminin V were measured. RESULTS: The strained HLECs were elongated and aligned perpendicular to the direction of force. Fibronectin and laminin V were highly expressed in the strain group compared with the control. CONCLUSIONS: Cyclic strain induces the synthesis of fibronectin and laminin V in cultivated HLECs.
ISSN
0271-3683 (Print)
Language
English
URI
http://www.informaworld.com/smpp/content~db=all?content=10.1080/02713680601038832

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17169839

http://hdl.handle.net/10371/15704
DOI
https://doi.org/10.1080/02713680601038832
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Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Ophthalmology (안과학전공)Journal Papers (저널논문_안과학전공)
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