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Effect of mechanical strain on human limbal epithelial cells in vitro
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Joo Youn | - |
dc.contributor.author | Jung, Kyoung Ah | - |
dc.contributor.author | Kim, Mee Kum | - |
dc.contributor.author | Wee, Won Ryang | - |
dc.contributor.author | Lee, Jin Hak | - |
dc.date.accessioned | 2009-11-26T02:59:27Z | - |
dc.date.available | 2009-11-26T02:59:27Z | - |
dc.date.issued | 2006-12-16 | - |
dc.identifier.citation | Curr Eye Res. 2006 Dec;31(12):1015-20. | en |
dc.identifier.issn | 0271-3683 (Print) | - |
dc.identifier.uri | http://www.informaworld.com/smpp/content~db=all?content=10.1080/02713680601038832 | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17169839 | - |
dc.identifier.uri | https://hdl.handle.net/10371/15704 | - |
dc.description.abstract | PURPOSE: To investigate the effects of the mechanical cyclic strain on the extracellular matrix (ECM) production by cultivated human limbal epithelial cells (HLECs) in vitro. METHODS: HLECs were repetitively stretched and relaxed by 20% of their original length. Morphology of HLECs was observed, and concentrations of fibronectin and laminin V were measured. RESULTS: The strained HLECs were elongated and aligned perpendicular to the direction of force. Fibronectin and laminin V were highly expressed in the strain group compared with the control. CONCLUSIONS: Cyclic strain induces the synthesis of fibronectin and laminin V in cultivated HLECs. | en |
dc.language.iso | en | - |
dc.publisher | Taylor & Francis | en |
dc.subject | Blotting, Western | en |
dc.subject | Cell Adhesion Molecules/*biosynthesis | en |
dc.subject | Cell Shape | en |
dc.subject | Cells, Cultured | en |
dc.subject | Enzyme-Linked Immunosorbent Assay | en |
dc.subject | Epithelial Cells/*physiology | en |
dc.subject | Extracellular Matrix/*metabolism | en |
dc.subject | Fibronectins/*biosynthesis | en |
dc.subject | Humans | en |
dc.subject | Limbus Corneae/*cytology | en |
dc.subject | Stress, Mechanical | en |
dc.title | Effect of mechanical strain on human limbal epithelial cells in vitro | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 오주연 | - |
dc.contributor.AlternativeAuthor | 정경아 | - |
dc.contributor.AlternativeAuthor | 김미금 | - |
dc.contributor.AlternativeAuthor | 위원량 | - |
dc.contributor.AlternativeAuthor | 이진학 | - |
dc.identifier.doi | 10.1080/02713680601038832 | - |
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