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Long-term protection against hepatitis B in pediatric liver recipients can be achieved effectively with vaccination after transplantation

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dc.contributor.authorKwon, Choon Hyuck David-
dc.contributor.authorSuh, Kyung-Suk-
dc.contributor.authorYi, Nam-Joon-
dc.contributor.authorChang, Seong-Hwan-
dc.contributor.authorCho, Yong Beom-
dc.contributor.authorCho, Jai-Young-
dc.contributor.authorLee, Hoan Jong-
dc.contributor.authorSeo, Jeong Kee-
dc.contributor.authorLee, Kuhn Uk-
dc.date.accessioned2009-11-26T03:03:29Z-
dc.date.available2009-11-26T03:03:29Z-
dc.date.issued2006-05-23-
dc.identifier.citationPediatr Transplant. 2006 Jun;10(4):479-86en
dc.identifier.issn1397-3142 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16712607-
dc.identifier.urihttps://hdl.handle.net/10371/15722-
dc.description.abstractLiver recipients who have antibodies to hepatitis B core antigen (anti-HBc) or received an anti-HBc positive liver graft are at risk of acquiring de novo hepatitis B infection so a life long prophylaxis is required. A post-transplant vaccination against hepatitis B virus (HBV) can offer a better alternative than either hepatitis B hyperimmune globulin (HBIG) or lamivudine. This study investigated the course of anti-HBs titer after vaccination and analyzed the factors that influence the response. Between October 1999 and February 2003, 37 pediatric patients were given a post-transplant vaccination when an anti-HBc positive graft was used, the recipient was anti-HBc positive, or when anti-HBs titer was below 20 IU/L irrespective of the serological status. Thirty-three patients responded to the vaccine and did not require further HBIG injections at a mean follow up of 33.6 months. Fifteen patients were good responder and only needed a single set of vaccines, and 18 were poor responder needing additional boosters. Two patients developed de novo hepatitis B infection and two required additional HBIG injections. Preoperative severity of liver disease, serological status of HBV of recipient or donor, use of HBIG or pulse steroid therapy, type of vaccines, and dose or time interval between doses had no influence on response rate. Recipients with a high preoperative anti-HB titer, small graft-recipient weight ratio (GRWR), greater catch up growth, heavier body weight, lower tacrolimus level at the time of vaccination, and longer time interval between transplant or steroid medication and vaccination yielded good response. If well tailored, post-transplant vaccination can be effective and offer patients prophylaxis against de novo hepatitis B infection for a prolonged period of time.en
dc.language.isoenen
dc.publisherBlackwell Publishingen
dc.subjectCadaveren
dc.subjectFemaleen
dc.subjectFollow-Up Studiesen
dc.subjectHepatitis B/blood/*prevention & controlen
dc.subjectHepatitis B Antibodies/analysisen
dc.subjectHepatitis B Core Antigens/analysisen
dc.subjectHepatitis B Vaccines/*therapeutic useen
dc.subjectHumansen
dc.subjectImmunization, Secondary/statistics & numerical dataen
dc.subjectImmunoglobulins/therapeutic useen
dc.subjectInfanten
dc.subjectLiving Donors/statistics & numerical dataen
dc.subjectMaleen
dc.subjectProspective Studiesen
dc.subjectRecombinant Proteins/therapeutic useen
dc.subjectTime Factorsen
dc.subjectTreatment Outcomeen
dc.subjectLiver Transplantation-
dc.subjectVaccination-
dc.titleLong-term protection against hepatitis B in pediatric liver recipients can be achieved effectively with vaccination after transplantationen
dc.typeArticleen
dc.contributor.AlternativeAuthor서경석-
dc.contributor.AlternativeAuthor이남준-
dc.contributor.AlternativeAuthor장성환-
dc.contributor.AlternativeAuthor조용범-
dc.contributor.AlternativeAuthor조재영-
dc.contributor.AlternativeAuthor이환종-
dc.contributor.AlternativeAuthor서정기-
dc.contributor.AlternativeAuthor이건욱-
dc.identifier.doi10.1111/j.1399-3046.2006.00540.x-
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