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The role of clusterin in in vitro ischemia of human retinal endothelial cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jeong Hun | - |
dc.contributor.author | Yu, Young Suk | - |
dc.contributor.author | Kim, Jin Hyoung | - |
dc.contributor.author | Kim, Kyu-Won | - |
dc.contributor.author | Min, Bon-Hong | - |
dc.date.accessioned | 2009-11-26T03:29:35Z | - |
dc.date.available | 2009-11-26T03:29:35Z | - |
dc.date.issued | 2007-09-14 | - |
dc.identifier.citation | Curr Eye Res. 2007 Jul-Aug;32(7-8):693-8. | en |
dc.identifier.issn | 0271-3683 (Print) | - |
dc.identifier.uri | http://www.informaworld.com/smpp/content~db=all?content=10.1080/02713680701487871 | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17852194 | - |
dc.identifier.uri | https://hdl.handle.net/10371/15771 | - |
dc.description.abstract | Clusterin has been reported to be up-regulated in diverse pathophysiological stresses, but its role is controversial. In this study, we investigated the role of clusterin under in vitro ischemia of human retinal endothelial cells (HRECs). When HRECs were exposed to oxygen-glucose deprivation (OGD), clusterin expression increased, whereas von Willebrand factor (vWF), occludin, and zonula occludens (ZO-1) markedly decreased. Interestingly, loss of tight junction proteins and death of HRECs in OGD conditions were restored by clusterin treatment. Our results suggest that the enhanced clusterin in OGD conditions may play a protective role against ischemia-induced tight junction protein loss and HRECs death. | en |
dc.language.iso | en | - |
dc.publisher | Taylor & Francis | en |
dc.subject | Apoptosis/drug effects | en |
dc.subject | Blood-Retinal Barrier/physiology | en |
dc.subject | Blotting, Western | en |
dc.subject | Cell Hypoxia | en |
dc.subject | Cell Survival | en |
dc.subject | Cells, Cultured | en |
dc.subject | Chromatography, Affinity | en |
dc.subject | Clusterin/pharmacology/*physiology | en |
dc.subject | Endothelium, Vascular/drug effects/*metabolism | en |
dc.subject | Glucose/deficiency | en |
dc.subject | Humans | en |
dc.subject | Indoles/metabolism | en |
dc.subject | Ischemia/*metabolism | en |
dc.subject | Membrane Proteins/metabolism | en |
dc.subject | Phosphoproteins/metabolism | en |
dc.subject | Retinal Vessels/*metabolism | en |
dc.subject | Staining and Labeling | en |
dc.subject | von Willebrand Factor/metabolism | en |
dc.title | The role of clusterin in in vitro ischemia of human retinal endothelial cells | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김정훈 | - |
dc.contributor.AlternativeAuthor | 유영석 | - |
dc.contributor.AlternativeAuthor | 김진형 | - |
dc.contributor.AlternativeAuthor | 김규원 | - |
dc.contributor.AlternativeAuthor | 민본홍 | - |
dc.identifier.doi | 10.1080/02713680701487871 | - |
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