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The role of clusterin in in vitro ischemia of human retinal endothelial cells

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dc.contributor.authorKim, Jeong Hun-
dc.contributor.authorYu, Young Suk-
dc.contributor.authorKim, Jin Hyoung-
dc.contributor.authorKim, Kyu-Won-
dc.contributor.authorMin, Bon-Hong-
dc.date.accessioned2009-11-26T03:29:35Z-
dc.date.available2009-11-26T03:29:35Z-
dc.date.issued2007-09-14-
dc.identifier.citationCurr Eye Res. 2007 Jul-Aug;32(7-8):693-8.en
dc.identifier.issn0271-3683 (Print)-
dc.identifier.urihttp://www.informaworld.com/smpp/content~db=all?content=10.1080/02713680701487871-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17852194-
dc.identifier.urihttp://hdl.handle.net/10371/15771-
dc.description.abstractClusterin has been reported to be up-regulated in diverse pathophysiological stresses, but its role is controversial. In this study, we investigated the role of clusterin under in vitro ischemia of human retinal endothelial cells (HRECs). When HRECs were exposed to oxygen-glucose deprivation (OGD), clusterin expression increased, whereas von Willebrand factor (vWF), occludin, and zonula occludens (ZO-1) markedly decreased. Interestingly, loss of tight junction proteins and death of HRECs in OGD conditions were restored by clusterin treatment. Our results suggest that the enhanced clusterin in OGD conditions may play a protective role against ischemia-induced tight junction protein loss and HRECs death.en
dc.language.isoen-
dc.publisherTaylor & Francisen
dc.subjectApoptosis/drug effectsen
dc.subjectBlood-Retinal Barrier/physiologyen
dc.subjectBlotting, Westernen
dc.subjectCell Hypoxiaen
dc.subjectCell Survivalen
dc.subjectCells, Cultureden
dc.subjectChromatography, Affinityen
dc.subjectClusterin/pharmacology/*physiologyen
dc.subjectEndothelium, Vascular/drug effects/*metabolismen
dc.subjectGlucose/deficiencyen
dc.subjectHumansen
dc.subjectIndoles/metabolismen
dc.subjectIschemia/*metabolismen
dc.subjectMembrane Proteins/metabolismen
dc.subjectPhosphoproteins/metabolismen
dc.subjectRetinal Vessels/*metabolismen
dc.subjectStaining and Labelingen
dc.subjectvon Willebrand Factor/metabolismen
dc.titleThe role of clusterin in in vitro ischemia of human retinal endothelial cellsen
dc.typeArticleen
dc.contributor.AlternativeAuthor김정훈-
dc.contributor.AlternativeAuthor유영석-
dc.contributor.AlternativeAuthor김진형-
dc.contributor.AlternativeAuthor김규원-
dc.contributor.AlternativeAuthor민본홍-
dc.identifier.doi10.1080/02713680701487871-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Ophthalmology (안과학전공)Journal Papers (저널논문_안과학전공)
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