Photoprotective and anti-skin-aging effects of eicosapentaenoic acid in human skin in vivo

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Kim, Hyeon Ho; Cho, Soyun; Lee, Serah; Kim, Kyu Han; Cho, Kwang Hyun; Eun, Hee Chul; Chung, Jin Ho
Issue Date
American Society for Biochemistry and Molecular Biology
J Lipid Res. 2006 May;47(5):921-30. Epub 2006 Feb 7.
AdultAgedCyclooxygenase 2/biosynthesisEicosapentaenoic Acid/*pharmacologyExtracellular Matrix/drug effectsGene Expression/radiation effectsHumansMAP Kinase Kinase 4/metabolism/radiation effectsMaleMatrix Metalloproteinase 1/biosynthesisMatrix Metalloproteinase 9/biosynthesisPhosphorylation/radiation effectsProcollagen/biosynthesis/radiation effectsProto-Oncogene Proteins c-jun/metabolism/radiation effectsRadiation-Protective Agents/*pharmacologySkin Aging/*drug effects/radiation effectsTransforming Growth Factor beta/biosynthesisTransforming Growth Factor beta1Transforming Growth Factor beta2Transforming Growth Factor beta3Ultraviolet Raysp38 Mitogen-Activated Protein Kinases/metabolism/radiation effects
Skin aging can be attributed to photoaging (extrinsic) and chronological (intrinsic) aging. Photoaging and intrinsic aging are induced by damage to human skin attributable to repeated exposure to ultraviolet (UV) irradiation and to the passage of time, respectively. In our previous report, eicosapentaenoic acid (EPA) was found to inhibit UV-induced matrix metalloproteinase-1 (MMP-1) expression in human dermal fibroblasts. Therefore, we investigated the effects of EPA on UV-induced skin damage and intrinsic aging by applying EPA topically to young and aged human skin, respectively. By immunohistochemical analysis and Western blotting, we found that topical application of EPA reduced UV-induced epidermal thickening and inhibited collagen decrease induced by UV light. It was also found that EPA attenuated UV-induced MMP-1 and MMP-9 expression by inhibiting UV-induced c-Jun phosphorylation, which is closely related to UV-induced activator protein-1 activation, and by inhibiting JNK and p38 activation. EPA also inhibited UV-induced cyclooxygenase-2 (COX-2) expression without altering COX-1 expression. Moreover, it was found that EPA increased collagen and elastic fibers (tropoelastin and fibrillin-1) expression by increasing transformin growth factor-beta expression in aged human skin. Together, these results demonstrate that topical EPA has potential as an anti-skin-aging agent.
0022-2275 (Print)
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College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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