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항결핵 약제 유발 간독성과 혈중 항결핵 약제 농도의 상관관계
Drug induced hepatotoxicity of anti-tuberculosis drug and their serum levels

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Authors
정인아
Advisor
이재호
Major
의학과 내과학전공
Issue Date
2011-02
Publisher
서울대학교 대학원
Keywords
결핵간독성약제모니터링Backgrounds: Hepatotoxicity is one of the most common adverse reaction of anti-tuberculosis(TB) treatment. Relatively little is known about hepatotoxicity and their serum levels of anti-TB drugs. Objective: To investigate the incidence of drug-induced hepatotoxicity (DIH) caused by anti-TB drugs and to identify the association of DIH and serum anti-tuberculosis drug concentrations. Methods: Serum levels of isoniazid (INH)rifampicin (RMP)ethambutol (EMB)pyrazinamide (PZA) were analysed by blood sample 2 hours after drug ingestion in patients on anti-TB treatment. DIH was investigated retrospectively and defined when liver enzyme exceed three times upper limit of normal. We compared serum drug level and other clinical factors between hepatotoxicity group and no-hepatotoxicity group. Patients with HIV co-infectionacute viral hepatitischronic liver diseasemalabsorption were excluded. Results: Between June 2006 and Feb 2010195 patients were included in the analysis. The median age of 195 patients(men 60%) was 46 yrs(range 16-92). Hepatotoxicity occurred in 19(9.7%) patients and their mean ASTALT was 245244. Among 19 patientsPZA related and INH or RMP related hepatotoxicity was estimated in 9 and 8 patients respectively. Howeverserum levels of four anti-TB drugs did not differ statistically between hepatotoxicity and no-hepatotoxicity group. Agesexpast history of TBbody mass index(BMI) also did not show statistical difference. Conclusion: There were relatively small number of patients whose drug level exceeds reference range and serum drug level did not show relevance to DIH.
Description
학위논문 (석사)-- 서울대학교 대학원 : 의학과 내과학전공, 2011.2. 이재호.
Language
kor
URI
http://hdl.handle.net/10371/158312

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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Theses (Master's Degree_의학과)
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