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The hepatic regeneration power of mild steatotic grafts is not impaired in living-donor liver transplantation

Cited 38 time in Web of Science Cited 42 time in Scopus
Authors
Cho, Jai Young; Suh, Kyung-Suk; Kwon, Choon Hyuck; Yi, Nam-Joon; Cho, Soo Youn; Jang, Ja-June; Kim, Se Hyung; Lee, Kuhn Uk
Issue Date
2005-01-25
Publisher
John Wiley & Sons
Citation
Liver Transpl. 2005 Feb;11(2):210-7
Keywords
AdultFatty Liver/*physiopathologyFemaleHumansImmunohistochemistryLiver/metabolismLiver Regeneration/*physiology*Liver Transplantation/physiologyLiving DonorsMaleMiddle Aged
Abstract
The aim of this study was to assess histologic changes in steatotic grafts, regenerative capacity, and the outcome of steatotic grafts in living-donor liver transplantation (LDLT). Between September 2002 and February 2004, 55 cases of LDLT with a liver biopsy performed on the 10th postoperative day were enrolled. Patients were grouped according to the intraoperative histologic degree of macrovesicular steatosis (MaS) as follows: Group 1, <5% (n = 24); Group 2, 5 to 15% (n = 24); and Group 3, 15 to 30% (n = 7). The intraoperative microscopic findings and the findings on the 10th postoperative day were compared. Immunohistochemistry was performed using antibody of proliferating cell nuclear antigen (PCNA) and Ki-67 to assess the regeneration power of grafts on the 10th postoperative day. The histologic degree of MaS on postoperative day 10 decreased from 5.22 +/- 1.04% (mean +/- standard deviation) to 2.17 +/- 1.90 in Group 2 (P < .001) and from 21.4 +/- 8.02 to 4.43 +/- 2.70 in Group 3 (P = .003). The number of positively stained hepatocytes in 10 high power fields was 48.0 +/- 17.1, 53.8 +/- 14.4, and 51.5 +/- 4.1 in each group by PCNA (P = .681), and 24.0 +/- 14.0, 25.5 +/- 11.8, and 21.6 +/- 6.8 by Ki-67 (P = .825), respectively. No primary graft nonfunction (PNF) or delayed graft function (DGF) occurred. Major complications were comparable among groups. In conclusion, in LDLT, steatosis disappeared immediately after transplantation and hepatic regeneration power was not impaired in grafts with less than 30% of MaS. Furthermore, a mildly steatotic graft did not increase the risk of graft dysfunction or morbidity in LDLT.
ISSN
1527-6465 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15666394

http://hdl.handle.net/10371/15897
DOI
https://doi.org/10.1002/lt.20340
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College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
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