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Actual long-term outcome of extrahepatic bile duct cancer after surgical resection

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dc.contributor.authorJang, Jin-Young-
dc.contributor.authorKim, Sun-Whe-
dc.contributor.authorPark, Do Joong-
dc.contributor.authorAhn, Young Joon-
dc.contributor.authorYoon, Yoo-Seok-
dc.contributor.authorChoi, Min Gew-
dc.contributor.authorSuh, Kyung-Suk-
dc.contributor.authorLee, Kuhn Uk-
dc.contributor.authorPark, Yong-Hyun-
dc.date.accessioned2009-11-26T05:18:40Z-
dc.date.available2009-11-26T05:18:40Z-
dc.date.issued2004-12-29-
dc.identifier.citationAnn Surg. 2005 Jan;241(1):77-84en
dc.identifier.issn0003-4932 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve-
dc.identifier.urihttp://hdl.handle.net/10371/15918-
dc.description.abstractOBJECTIVES: The objectives of this study were to analyze the actual long-term outcome after the surgical resection of extrahepatic bile duct cancer and to identify the characteristics shared by long-term survivors (5 years or longer). SUMMARY BACKGROUND DATA: Although reported 5-year survival rates of extrahepatic bile duct cancer lie between 20% and 30%, these data are not reflecting the actual cure rate. Some patients survive longer than 5 years with recurrent disease. In some patients, recurrence is detected after 5 years. Accordingly, true cure rate is probably substantially lower than the 5-year survival rate. METHODS: One hundred fifty-one patients from a total of 282 patients with extrahepatic bile duct cancer (excluding ampulla of Vater cancer) underwent surgical resection between 1986 and 1997. We analyzed the actual survival outcome and postresection prognostic factors after resection, which included hepatobiliary resection (HBR; extended either right or left hepatectomy, caudate lobectomy, and hilar bile duct resection, n = 23), bile duct resection (BDR; n = 25), and pancreatoduodenectomy (PD; n = 103). We also compared the clinicopathologic characteristics of actual long-term survivors (n = 49) with those who survived longer than 5 years and with short-term (<5 years) survivors. RESULTS: Forty-nine of the 151 resection cases (32.5%) survived 5 years or longer; there was no 5-year survivor in the nonresected cases. The actual 5-year survival rate was 47.8% after HBR (11 of 23), 28.0% after BDR (7 of 25), and 30.1% after PD (31 of 103) (P = 0.083). Tumor histology and lymph node metastasis were identified as independent prognostic factors by multivariate analysis. Some long-term survivors had poor postoperative prognostic factors such as T3, lymph node metastasis, or microscopic margin involvement, but none with a poorly differentiated tumor. Seven long-term survivors had recurrent disease at 5 years, and recurrence was detected after 5 years in 8 more patients. Therefore, the actual cure rate (<19.2%) was substantially less than the 5-year survival rate. CONCLUSIONS: In cases of extrahepatic bile duct cancer, resection should be considered and efforts should be made to obtain a tumor-free margin. An aggressive surgical approach will give some survival benefit to the patients with even advanced disease. Long-term follow up is needed before declaring "a cure," because late recurrence after 5 years is detected not infrequently. Adjuvant therapy, local and systemic, needs to be further developed.en
dc.language.isoen-
dc.publisherLippincott Williams and Wilkinsen
dc.subjectAgeden
dc.subjectBile Duct Neoplasms/mortality/*surgeryen
dc.subjectBile Ducts, Extrahepatic/*surgeryen
dc.subjectBiliary Tract Surgical Procedures/*methods/mortalityen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNeoplasm Recurrence, Local/mortalityen
dc.subjectPrognosisen
dc.subjectSurvival Analysisen
dc.subjectTreatment Outcomeen
dc.titleActual long-term outcome of extrahepatic bile duct cancer after surgical resectionen
dc.typeArticleen
dc.contributor.AlternativeAuthor장진영-
dc.contributor.AlternativeAuthor김선회-
dc.contributor.AlternativeAuthor박도중-
dc.contributor.AlternativeAuthor안영준-
dc.contributor.AlternativeAuthor윤유석-
dc.contributor.AlternativeAuthor최민규-
dc.contributor.AlternativeAuthor서경숙-
dc.contributor.AlternativeAuthor이건욱-
dc.contributor.AlternativeAuthor박용현-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
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