Vascular endothelial growth factor gene +405 C/G polymorphism is associated with susceptibility to advanced stage endometriosis

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Kim, Sung Hoon; Choi, Young Min; Choung, Seon Ha; Jun, Jong Kwan; Kim, Jung Gu; Moon, Shin Yong
Issue Date
Oxford University Press
Hum Reprod. 2005 Oct;20(10):2904-8. Epub 2005 Jun 24
AllelesCase-Control StudiesEndometriosis/*geneticsFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHaplotypesHumansKoreaOdds Ratio*Polymorphism, GeneticPolymorphism, Restriction Fragment LengthSequence Analysis, DNAVascular Endothelial Growth Factor A/*genetics/metabolism
BACKGROUND: Vascular endothelial growth factor (VEGF) is known to play a pivotal role in the development of endometriosis. This study was performed to investigate whether the VEGF gene 5'-untranslated region polymorphism is associated with susceptibility to advanced stage endometriosis. METHODS: This study comprised 215 women with advanced stage endometriosis, 219 control women without endometriosis, and 70 fertile women. Following extraction of genomic DNA, genotyping of the -460 C/T and +405 C/G polymorphisms of the VEGF gene were performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. RESULTS: The distribution of genotypes and allele frequencies of the -460 C/T polymorphism in the endometriosis group did not differ from those in the control group and the fertile women group. However, genotype distribution of the +405 C/G polymorphism was significantly different between patients with and without endometriosis (P = 0.01) and between patients with endometriosis and the fertile women (P = 0.02). Patients with endometriosis showed a higher incidence of the +405 CC genotype compared with the controls and the fertile women (P = 0.007 and 0.016 respectively). CONCLUSIONS: These findings suggest that the VEGF +405 C/G polymorphism may be associated with the risk of advanced stage endometriosis in the Korean population.
0268-1161 (Print)
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College of Medicine/School of Medicine (의과대학/대학원)Obstetrics & Gynecology (산부인과전공)Journal Papers (저널논문_산부인과학전공)
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