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Genetic polymorphism of XRCC3 Thr241Met and breast cancer risk: case-control study in Korean women and meta-analysis of 12 studies

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Authors
Lee, Sang-Ah; Lee, Kyoung-Mu; Park, Sue Kyung; Choi, Ji-Yeob; Kim, Bongcheol; Nam, Jinwu; Yoo, Keun-Young; Noh, Dong-Young; Ahn, Sei-Hyun; Kang, Daehee
Issue Date
2006-10-26
Publisher
Springer Verlag
Citation
Breast Cancer Res Treat. 2007 May;103(1):71-6. Epub 2006 Oct 25
Keywords
Asian Continental Ancestry Group/*geneticsBreast Neoplasms/epidemiology/*geneticsCase-Control StudiesDNA-Binding Proteins/*geneticsEuropean Continental Ancestry Group/geneticsFemaleGenetic Predisposition to Disease/epidemiology/*geneticsHumansKorea/epidemiologyMiddle Aged*Polymorphism, Genetic
Abstract
To evaluate the relationship of genetic polymorphism in XRCC3 Thr(241)Met and the risk of breast cancer, a hospital-based case-control study was conducted in Korea. Histologically confirmed breast cancer cases (n = 574) and controls (n = 502) with no present or previous history of cancer were recruited from several teaching hospitals in Seoul during 1995-2001. Information on demographic characteristics and other information were collected by interviewed questionnaire. Genetic polymorphisms of XRCC3 Thr(241)Met (C > T) was determined by single base extention assay. The frequency of Thr/Thr, Thr/Met, and Met/Met genotype were 89.4, 10.4, 0.2% in cases and 92.3, 7.7, 0.0% in controls, respectively. Genotype distribution in controls fit well to the Hardy-Weinberg equilibrium (P = 0.74). XRCC3 codon 241 Thr/Met or Met/Met genotype moderately increased the risk of breast cancer (OR = 1.4, 95% CI: 0.87-2.33), but not significant in this study. In the results of meta-analysis using twelve reports, however, Thr/Met or Met/Met genotype increased the risk of breast cancer (OR = 1.08, 95%CI: 1.00-1.17). In conclusion, although the genetic polymorphism of XRCC3 Thr(241)Met was unlikely to have a substantial overall association in Korean women, the meta-analysis of studies, including ours, provided that Thr/Met and Met/Met was weakly increased the risk of breast cancer compare to Thr/Thr genotype.
ISSN
0167-6806 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17063279

http://hdl.handle.net/10371/15969
DOI
https://doi.org/10.1007/s10549-006-9348-z
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College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
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