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The comparison of the impact of arterial stiffness and central pressure on left ventricular geometry and diastolic function

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Authors
Kim, Hack-Lyoung; Lim, Woo-Hyun; Seo, Jae-Bin; Kim, Sang-Hyun; Zo, Zoo-Hee; Kim, Myung-A
Issue Date
2019-09-01
Publisher
BioMed Central
Citation
Clinical Hypertension, 25(1):18
Keywords
Arterial stiffnessCentral blood pressureDiastolic functionLeft ventricleMorphology
Abstract
Background
This study was performed to compare the associations of brachial-ankle pulse wave velocity (baPWV) and central blood pressure (CBP) measurements with left ventricular (LV) geometry and diastolic function.

Methods
A total of 77 subjects (64.5 ± 10.8 years, 67.5% females) without documented cardiovascular disease were prospectively recruited. All subjects underwent transthoracic echocardiography, baPWV and noninvasive measurement of CBP on the same day.

Results
In simple linear correlation analyses, neither baPWV nor CBP was associated with LV mass index or relative wall thickness (P > 0.05 for each). Although baPWV significantly correlated with septal e´ velocity in simple linear correlation analyses (r = 0.258, P = 0.025), the significance was lost after controlling for potential confounder (P = 0.881). In simple linear correlation analyses, central systolic blood pressure (CSBP) and central pulse pressure (CPP) significantly correlated with both septal e´ velocity or E/e´ (P <  0.05 for each); however, neither central diastolic nor mean arterial pressures was associated with both septal e´ velocity and E/e´ (P > 0.05 for each). After controlling for confounders, including age, sex and body mass index, CSBP correlated with septal e´ velocity (β = − 0.258, P = 0.025), but not with E/e´ (P = 0.074). CPP correlated with both septal e´ velocity (β = − 0.300, P = 0.014) and E/e´ (β = 0.428, P = 0.002) in the same multivariable model.

Conclusions
In subjects without documented cardiovascular disease, CSBP and CPP may be more strongly associated with LV diastolic function than baPWV. Further studies with a larger sample size are needed to confirm our results.
ISSN
2056-5909
Language
English
URI
http://hdl.handle.net/10371/162634
DOI
https://doi.org/10.1186/s40885-019-0125-9
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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