Browse

Electromechanical cardioplasty using a wrapped elasto-conductive epicardial mesh

Cited 50 time in Web of Science Cited 94 time in Scopus
Authors
Park, Jinkyung; Choi, Suji; Janardhan, Ajit H.; Lee, Se-Yeon; Raut, Samarth; Soares, Joao; Shin, Kwangsoo; Yang, Shixuan; Lee, Chungkeun; Kang, Ki-Woon; Cho, Hye Rim; Kim, Seok Joo; Seo, Pilseon; Hyun, Wonji; Jung, Sungmook; Lee, Hye-Jeong; Lee, Nohyun; Choi, Seung Hong; Sacks, Michael; Lu, Nanshu; Josephson, Mark E.; Hyeon, Taeghwan; Kim, Dae-Hyeong; Hwang, Hye Jin
Issue Date
2016-06
Citation
Science Translational Medicine, Vol.8 No.344, p. 344ra86
Abstract
Heart failure remains a major public health concern with a 5-year mortality rate higher than that of most cancers. Myocardial disease in heart failure is frequently accompanied by impairment of the specialized electrical conduction system and myocardium. We introduce an epicardial mesh made of electrically conductive and mechanically elastic material, to resemble the innate cardiac tissue and confer cardiac conduction system function, to enable electromechanical cardioplasty. Our epicardium-like substrate mechanically integrated with the heart and acted as a structural element of cardiac chambers. The epicardial device was designed with elastic properties nearly identical to the epicardial tissue itself and was able to detect electrical signals reliably on the moving rat heart without impeding diastolic function 8 weeks after induced myocardial infarction. Synchronized electrical stimulation over the ventricles by the epicardial mesh with the high conductivity of 11,210 S/cm shortened total ventricular activation time, reduced inherent wall stress, and improved several measures of systolic function including increases of 51% in fractional shortening, similar to 90% in radial strain, and 42% in contractility. The epicardial mesh was also capable of delivering an electrical shock to terminate a ventricular tachyarrhythmia in rodents. Electromechanical cardioplasty using an epicardial mesh is a new pathway toward reconstruction of the cardiac tissue and its specialized functions.
ISSN
1946-6234
URI
http://hdl.handle.net/10371/164311
DOI
https://doi.org/10.1126/scitranslmed.aad8568
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Chemical Convergence for Energy and Environment (에너지환경 화학융합기술전공)Journal Papers (저널논문_에너지환경 화학융합기술전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse