Publications
Detailed Information
Bioresorbable Electronic Stent Integrated with Therapeutic Nanoparticles for Endovascular Diseases
Cited 182 time in
Web of Science
Cited 188 time in Scopus
- Authors
- Issue Date
- 2015-06
- Publisher
- American Chemical Society
- Citation
- ACS Nano, Vol.9 No.6, pp.5937-5946
- Abstract
- Implantable endovascular devices such as bare metal, drug eluting, and bioresorbable stents have transformed interventional care by providing continuous structural and mechanical support to many peripheral, neural, and coronary arteries affected by blockage. Although effective in achieving immediate restoration of blood flow, the long-term re-endothelialization and inflammation induced by mechanical stents are difficult to diagnose or treat. Here we present nanomaterial designs and integration strategies for the bioresorbable electronic stent with drug-infused functionalized nanoparticles to enable flow sensing, temperature monitoring, data storage, wireless power/data transmission, inflammation suppression, localized drug delivery, and hyperthermia therapy. In vivo and ex vivo animal experiments as well as in vitro cell studies demonstrate the previously unrecognized potential for bioresorbable electronic implants coupled with bioinert therapeutic nanoparticles in the endovascular system.
- ISSN
- 1936-0851
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.