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Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo

Cited 577 time in Web of Science Cited 622 time in Scopus
Authors
Viventi, Jonathan; Kim, Dae-Hyeong; Vigeland, Leif; Frechette, Eric S.; Blanco, Justin A.; Kim, Yun-Soung; Avrin, Andrew E.; Tiruvadi, Vineet R.; Hwang, Suk-Won; Vanleer, Ann C.; Wulsin, Drausin F.; Davis, Kathryn; Gelber, Casey E.; Palmer, Larry; Van der Spiegel, Jan; Wu, Jian; Xiao, Jianliang; Huang, Yonggang; Contreras, Diego; Rogers, John A.; Litt, Brian
Issue Date
2011-12
Citation
Nature Neuroscience, Vol.14 No.12, pp.1599-1605
Abstract
Arrays of electrodes for recording and stimulating the brain are used throughout clinical medicine and basic neuroscience research, yet are unable to sample large areas of the brain while maintaining high spatial resolution because of the need to individually wire each passive sensor at the electrode-tissue interface. To overcome this constraint, we developed new devices that integrate ultrathin and flexible silicon nanomembrane transistors into the electrode array, enabling new dense arrays of thousands of amplified and multiplexed sensors that are connected using fewer wires. We used this system to record spatial properties of cat brain activity in vivo, including sleep spindles, single-trial visual evoked responses and electrographic seizures. We found that seizures may manifest as recurrent spiral waves that propagate in the neocortex. The developments reported here herald a new generation of diagnostic and therapeutic brain-machine interface devices.
ISSN
1097-6256
URI
http://hdl.handle.net/10371/164357
DOI
https://doi.org/10.1038/nn.2973
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Chemical Convergence for Energy and Environment (에너지환경 화학융합기술전공)Journal Papers (저널논문_에너지환경 화학융합기술전공)
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