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Large scale and integrated platform for digital mass culture of anchorage dependent cells

Cited 3 time in Web of Science Cited 4 time in Scopus
Authors
Cho, Kyoung Won; Kim, Seok Joo; Kim, Jaemin; Song, Seuk Young; Lee, Wang Hee; Wang, Liu; Soh, Min; Lu, Nanshu; Hyeon, Taeghwan; Kim, Byung-Soo; Kim, Dae-Hyeong
Issue Date
2019-10
Citation
Nature Communications, Vol.10, p. 4824
Abstract
Industrial applications of anchorage-dependent cells require large-scale cell culture with multifunctional monitoring of culture conditions and control of cell behaviour. Here, we introduce a large-scale, integrated, and smart cell-culture platform (LISCCP) that facilitates digital mass culture of anchorage-dependent cells. LISCCP is devised through large-scale integration of ultrathin sensors and stimulator arrays in multiple layers. LISCCP provides real-time, 3D, and multimodal monitoring and localized control of the cultured cells, which thereby allows minimizing operation labour and maximizing cell culture performance. Wireless integration of multiple LISCCPs across multiple incubators further amplifies the culture scale and enables digital monitoring and local control of numerous culture layers, making the large-scale culture more efficient. Thus, LISCCP can transform conventional labour-intensive and high-cost cell cultures into efficient digital mass cell cultures. This platform could be useful for industrial applications of cell cultures such as in vitro toxicity testing of drugs and cosmetics and clinical scale production of cells for cell therapy.
ISSN
2041-1723
URI
http://hdl.handle.net/10371/164515
DOI
https://doi.org/10.1038/s41467-019-12777-3
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Chemical Convergence for Energy and Environment (에너지환경 화학융합기술전공)Journal Papers (저널논문_에너지환경 화학융합기술전공)
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