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Antitumor effect of TW-37, a BH3 mimetic in human oral cancer

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Authors
Ahn, Chi-Hyun; Lee, Won Woo; Jung, Yun Chan; Shin, Ji-Ae; Hong, Kyoung-Ok; Choi, Sujung; Swarup, Neeti; Kim, Jihoon; Ahn, Min-Hye; Jung, Minjung; Cho, Sung-Dae; Jin, Bohwan
Issue Date
2019-12-04
Publisher
BMC
Citation
Laboratory Animal Research, 35(1):27
Keywords
TW-37ApoptosisBcl-2Oral cancer
Abstract
TW-37 is a small molecule B cell lymphoma-2 (Bcl-2) homology 3 mimetic with potential anticancer activities. However, the in vivo anti-cancer effect of TW-37 in human oral cancer has not been properly studied yet. Here, we attempted to confirm antitumor activity of TW37 in human oral cancer. TW-37 significantly inhibited cell proliferation and increased the number of dead cells in MC-3 and HSC-3 human oral cancer cell lines. TW-37 enhanced apoptosis of both cell lines evidenced by annexin V/propidium iodide double staining, sub-G1 population analysis and the detection of cleaved poly (ADP-ribose) polymerase and caspase-3. In addition, TW-37 markedly downregulated the expression of Bcl-2 protein, while not affecting Bcl-xL or myeloid cell leukemia-1. In vivo, TW-37 inhibited tumor growth in a nude mice xenograft model without any significant liver and kidney toxicities. Collectively, these data reveal that TW-37 may be a promising small molecule to inhibit human oral cancer.
ISSN
2233-7660
Language
English
URI
https://doi.org/10.1186/s42826-019-0028-7

http://hdl.handle.net/10371/164791
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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