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Core transcriptional regulatory circuits in prion diseases
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Taek-Kyun | - |
dc.contributor.author | Lee, Inyoul | - |
dc.contributor.author | Cho, Ji-Hoon | - |
dc.contributor.author | Canine, Brenda | - |
dc.contributor.author | Keller, Andrew | - |
dc.contributor.author | Price, Nathan D | - |
dc.contributor.author | Hwang, Daehee | - |
dc.contributor.author | Carlson, George | - |
dc.contributor.author | Hood, Leroy | - |
dc.date.accessioned | 2020-04-06T08:19:12Z | - |
dc.date.available | 2020-04-06T17:19:56Z | - |
dc.date.issued | 2020-01-20 | - |
dc.identifier.citation | Molecular Brain, 13(1):10 | ko_KR |
dc.identifier.issn | 1756-6606 | - |
dc.identifier.uri | 10.1186/s13041-020-0551-3 | - |
dc.identifier.uri | https://hdl.handle.net/10371/164927 | - |
dc.description.abstract | Complex diseases involve dynamic perturbations of pathophysiological processes during disease progression. Transcriptional programs underlying such perturbations are unknown in many diseases. Here, we present core transcriptional regulatory circuits underlying early and late perturbations in prion disease. We first identified cellular processes perturbed early and late using time-course gene expression data from three prion-infected mouse strains. We then built a transcriptional regulatory network (TRN) describing regulation of early and late processes. We found over-represented feed-forward loops (FFLs) comprising transcription factor (TF) pairs and target genes in the TRN. Using gene expression data of brain cell types, we further selected active FFLs where TF pairs and target genes were expressed in the same cell type and showed correlated temporal expression changes in the brain. We finally determined core transcriptional regulatory circuits by combining these active FFLs. These circuits provide insights into transcriptional programs for early and late pathophysiological processes in prion disease. | ko_KR |
dc.description.sponsorship | This study was supported by the grants from the Luxembourg Centre for Systems Biomedicine and the University of Luxembourg, Genetics of Prion Susceptibility in vitro (NIH P01 NS041997), Center for Systems Biology (NIH 2P50GM076547-06A), DOD Awards (W911NF-10-2-0111, W81XWH-09-1-0107 and DAMD17–03-1-0321), and the Institute for Basic Science (IBS-R013-A1)
from Korean Ministry of Science and ICT. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Murine PrP-prion disease | - |
dc.subject | Gene expression | - |
dc.subject | Transcriptional regulatory circuits | - |
dc.subject | Feed-forward loops | - |
dc.subject | Brain cell type | - |
dc.title | Core transcriptional regulatory circuits in prion diseases | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김택균 | - |
dc.contributor.AlternativeAuthor | 이인율 | - |
dc.contributor.AlternativeAuthor | 조지훈 | - |
dc.contributor.AlternativeAuthor | 황대희 | - |
dc.citation.journaltitle | Molecular Brain | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2020-01-26T04:14:18Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 10 | ko_KR |
dc.citation.volume | 13 | ko_KR |
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