Browse

Clinical outcomes of radiation-based locoregional therapy in locally advanced head and neck squamous cell carcinoma patients not responding to induction chemotherapy

Cited 7 time in Web of Science Cited 7 time in Scopus
Authors
Lim, Yoojoo; Keam, Bhumsuk; Koh, Youngil; Kim, Tae Min; Lee, Se-Hoon; Hah, J. Hun; Kwon, Tack-Kyun; Kim, Dong-Wan; Wu, Hong-Gyun; Sung, Myung-Whun; Heo, Dae Seog; Kim, Kwang Hyun
Issue Date
2013-07
Citation
Oral Surgery Oral Medicine Oral Pathology Oral Radiology, Vol.116 No.1, pp.55-60
Abstract
Objective. The purpose of this study was to evaluate the efficacy of radiation-based locoregional therapy for locally advanced head and neck squamous cell carcinoma (LA-HNSCC) patients who did not respond to induction chemotherapy (IC). Study Design. Outcomes after radiation-based locoregional therapy were retrospectively analyzed. Results. Among a total of 208 patients treated with IC, 46 (22.1%) did not respond. After IC, patients were treated with radiotherapy (RT), concurrent chemoradiotherapy (CCRT), or surgery with or without postoperative RT. Among the 46 nonresponders, 17 (37.8%) patients underwent surgery and 28 (62.2%) were treated with RT or CCRT. Responses to subsequent RT or CCRT for 26 evaluable patients were as follows: complete response = 7 (26.9%), partial response = 9 (34.6%), stable disease = 4 (15.4%), and progressive disease = 6 (23.1%). Conclusion. A significant proportion of LA-HNSCC patients who did not respond to IC can benefit from subsequent RT or CCRT.
ISSN
2212-4403
URI
http://hdl.handle.net/10371/165460
DOI
https://doi.org/10.1016/j.oooo.2013.02.007
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Cancer Research Institute (암연구소)Journal Papers (저널논문_암연구소)
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse