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Definitive Radiotherapy versus Postoperative Radiotherapy for Tonsil Cancer

Cited 3 time in Web of Science Cited 3 time in Scopus
Authors
Koo, Tae Ryool; Wu, Hong-Gyun; Hah, J. Hun; Sung, Myung-Whun; Kim, Kwang Hyun; Keam, Bhumsuk; Kim, Tae Min; Lee, Se-Hoon; Kim, Dong-Wan; Heo, Dae Seog; Park, Charn Il
Issue Date
2012-12
Citation
Cancer Research and Treatment, Vol.44 No.4, pp.227-234
Keywords
Tonsil neoplasmsChemoradiotherapyIntensity-modulated radiotherapy
Abstract
Purpose The purpose of this study is to analyze treatment outcome of radiotherapy (RI) in patients with stage III-IV tonsil cancer managed by surgery followed by postoperative RI (SRT) and definitive chemoradiotherapy (CRT), and to thereby evaluate the most feasible treatment modality. Materials and Methods Of 124 patients, 67 underwent CRT, and 57 underwent SRT. We compared survival and complication rates in both groups. Results The median follow-up time was 57 months (range, 19 to 255 months) for surviving patients. At five years, locoregional progression-free survival (LRPFS) and overall survival (OS) were 88% and 80%, respectively. No significant difference in LRPFS (p=0.491) and OS (p=0.177) was observed between CRT and SRT. In multivariate analysis, old age and higher T stage showed a significant association with poor LRPFS, PFS, and OS; higher N stage showed an association with poor PFS and a trend of poor LRPFS, while no association with OS was observed; treatment modality (CRT and SRT) showed no association with LRFPS, PFS, and OS. Grade 3 or higher mucositis was observed in 12 patients (21%) in the SRT group, and 25 patients (37%) in the CRT group. Conclusion Definitive CRT and SRT have similar treatment outcomes for patients with stage III-IV tonsil cancer. Although acute complication rate appears to be higher in the CRT group, it should be noted that not all data on complications were included in this retrospective study. To determine the most feasible treatment modality, not only mucositis and xerostomia, but also emotional aspect and quality of life, should be considered.
ISSN
1598-2998
URI
http://hdl.handle.net/10371/165480
DOI
https://doi.org/10.4143/crt.2012.44.4.227
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College of Medicine/School of Medicine (의과대학/대학원)Cancer Research Institute (암연구소)Journal Papers (저널논문_암연구소)
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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