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Clinical dissection of multicentric Castleman disease

Cited 20 time in Web of Science Cited 19 time in Scopus
Authors
Shin, Dong-Yeop; Jeon, Yoon Kyung; Hong, Yong-Sang; Kim, Tae Min; Lee, Se-Hoon; Kim, Dong-Wan; Kim, Inho; Yoon, Sung-Soo; Heo, Dae Seog; Park, Seonyang; Kim, Byoung Kook
Issue Date
2011-08
Citation
Leukemia and Lymphoma, Vol.52 No.8, pp.1517-1522
Keywords
Castleman diseaseagesplenomegalyprognosisKaposi sarcoma-associated herpes virus
Abstract
This study investigated the prognostic factors of Castleman disease (CD) and focused specifically on multicentric CD (MCD). Seventy patients with CD were studied. Forty-three patients (61.5%) had unicentric CD (UCD) and 27 patients (38.5%) had MCD. Thirty-six patients with UCD (83.7%) underwent surgical excision, and 25 patients with MCD (92.6%) received systemic treatment, including corticosteroids and combination chemotherapy. In the patients with MCD, age >60 years and the presence of splenomegaly were prognostic factors for progression-free survival (hazard ratio [HR] 9.01, 95% confidence interval [CI] 2.64-30.83 and HR 4.32, 95% CI 1.16-16.09) as well as overall survival (OS) in MCD (HR 8.7, 95% CI 2.83-26.84 and HR 2.9, 95% CI 0.95-9.02, respectively). Patients <= 60 years old without splenomegaly showed better OS than patients >60 years old or with splenomegaly (71.4% vs. 10.8% for 5-year OS). MCD might be dissected clinically by the simple parameters of age and presence of splenomegaly.
ISSN
1042-8194
URI
http://hdl.handle.net/10371/165520
DOI
https://doi.org/10.3109/10428194.2011.574759
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College of Medicine/School of Medicine (의과대학/대학원)Cancer Research Institute (암연구소)Journal Papers (저널논문_암연구소)
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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