Browse

Neoadjuvant etoposide, ifosfamide, and cisplatin for the treatment of olfactory neuroblastoma

Cited 46 time in Web of Science Cited 56 time in Scopus
Authors
Kim, Dong-Wan; Jo, Yo-Han; Kim, Jee Hyun; Wu, Hong-Gyun; Rhee, Chae-Seo; Lee, Chol Hee; Kim, Tae-You; Heo, Dae Seog; Bang, Yung-Jue; Kim, Noe Kyeong
Issue Date
2004-11
Citation
Cancer, Vol.101 No.10, pp.2257-2260
Keywords
olfactory neuroblastomaesthesioneuroblastomachemotherapyetoposideifosfamidecisplatin
Abstract
BACKGROUND. The optimal chemotherapy regimen for the treatment of olfactory neuroblastoma has not been clearly defined. The purpose of the current study was to evaluate the efficacy of neoadjuvant chemotherapy with the combination of etoposide, ifosfamide, and cisplatin (VIP) for patients with olfactory neuroblastoma. METHODS. Eleven consecutive patients with newly diagnosed olfactory neuroblastoma were treated with etoposide (75 mg/m(2)), ifosfamide (1000 mg/m(2)), and cisplatin (20 mg/m(2)) all administered intravenously on Days 1-5. Cycles were repeated every 21 days. Patients were excluded from analysis if they had previously received surgery or radiotherapy. RESULTS. Nine patients achieved objective responses (objective response rate, 82%; 95% confidence interval, 52-95%), which included 2 complete responses and 7 partial responses. The major side effect was hematologic toxicity, with Grade 3/4 neutropenia observed after the receipt of 37% of all cycles and febrile neutropenia observed after the receipt of 2 cycles. All toxic events were reversible, and no chemotherapy-related deaths were documented. The median survival period was 18 months (range, 3-45 months). CONCLUSIONS. Neoadjuvant VIP chemotherapy was active in the treatment of olfactory neuroblastoma. Cancer 2004;101:2257-60. (C) 2005 American Cancer Society.
ISSN
0008-543X
URI
http://hdl.handle.net/10371/165570
DOI
https://doi.org/10.1002/cncr.20648
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Cancer Research Institute (암연구소)Journal Papers (저널논문_암연구소)
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse