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Pyrosequencing Analysis of Subgingival Microbiota in Distinct Periodontal Conditions

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dc.contributor.authorPark, O. -J.-
dc.contributor.authorYi, H.-
dc.contributor.authorJeon, J. H.-
dc.contributor.authorKang, S. -S.-
dc.contributor.authorKoo, K. -T.-
dc.contributor.authorKum, K. -Y.-
dc.contributor.authorChun, Jongsik-
dc.contributor.authorYun, Cheol-Heui-
dc.contributor.authorHan, Seung Hyun-
dc.date.accessioned2020-04-27T13:17:40Z-
dc.date.available2020-04-27T13:17:40Z-
dc.date.issued2015-07-
dc.identifier.citationJournal of Dental Research, Vol.94 No.7, pp.921-927-
dc.identifier.issn0022-0345-
dc.identifier.other11104-
dc.identifier.urihttp://hdl.handle.net/10371/165754-
dc.description.abstractSubgingival microorganisms are potentially associated with periodontal diseases. However, changes in the subgingival microbiota during the progress of periodontal diseases are poorly understood. In this study, we analyzed bacterial communities in the subgingival paper point samples from 32 Korean individuals with no sign of disease, gingivitis, or periodontitis using 454 FLX Titanium pyrosequencing. A total of 256,113 reads representing 26 phyla, 433 genera, and 1,016 species were detected. Bacteroidetes, Fusobacteria, Synergistetes, and Spirochaetes were the abundant phyla in periodontitis subjects, whereas Firmicutes and Proteobacteria were identified as the dominant phyla in the gingivitis and healthy subjects, respectively. Although high levels of Porphyromonas, Fusobacterium, Fretibacterium, Rothia, Filifactor, and Treponema genera were observed in the periodontitis subjects, Streptococcus, Capnocytophaga, Leptotrichia, and Haemophilus genera were found at high frequency in the gingivitis subjects. Species including Porphyromonas gingivalis, Fusobacterium nucleatum, and Fretibacterium fastidiosum were significantly increased in periodontitis subjects. On the other hand, Streptococcus pseudopneumoniae, Haemophilus parainfluenzae, and Leptotrichia hongkongensis were preferentially observed in the gingivitis subjects. Intriguingly, the halophile Halomonas hamiltonii was revealed as a predominant species in the healthy subjects. Based on Fast UniFrac analysis, distinctive bacterial clusters were classified for the healthy, gingivitis, and periodontitis state. The current findings might be useful for understanding the pathogenesis, diagnosis, and treatment of periodontal diseases.-
dc.subjectbacteria-
dc.subjectdental plaque-
dc.subjectgingival crevicular fluid-
dc.subjectgingivitis-
dc.subjectperiodontal pocket-
dc.subjectperiodontitis-
dc.titlePyrosequencing Analysis of Subgingival Microbiota in Distinct Periodontal Conditions-
dc.typeArticle-
dc.contributor.AlternativeAuthor구기태-
dc.contributor.AlternativeAuthor한승현-
dc.contributor.AlternativeAuthor윤철희-
dc.contributor.AlternativeAuthor금기연-
dc.contributor.AlternativeAuthor천종식-
dc.identifier.doi10.1177/0022034515583531-
dc.citation.journaltitleJournal of Dental Research-
dc.identifier.scopusid2-s2.0-84935145635-
dc.citation.endpage927-
dc.citation.number7-
dc.citation.startpage921-
dc.citation.volume94-
dc.identifier.urlhttp://journals.sagepub.com/doi/10.1177/0022034515583531-
dc.identifier.rimsid11104-
dc.identifier.sci000356621000009-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorChun, Jongsik-
Appears in Collections:
College of Natural Sciences (자연과학대학)Dept. of Biological Sciences (생명과학부)Journal Papers (저널논문_생명과학부)
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