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Telomere maintenance through recruitment of internal genomic regions
Cited 22 time in
Web of Science
Cited 21 time in Scopus
- Authors
- Issue Date
- 2015-09
- Publisher
- Nature Publishing Group
- Citation
- Nature Communications, Vol.6, p. 8189
- Abstract
- Cells surviving crisis are often tumorigenic and their telomeres are commonly maintained through the reactivation of telomerase. However, surviving cells occasionally activate a recombination-based mechanism called alternative lengthening of telomeres (ALT). Here we establish stably maintained survivors in telomerase-deleted Caenorhabditis elegans that escape from sterility by activating ALT. ALT survivors trans-duplicate an internal genomic region, which is already cis-duplicated to chromosome ends, across the telomeres of all chromosomes. These 'Template for ALT' (TALT) regions consist of a block of genomic DNA flanked by telomere-like sequences, and are different between two genetic background. We establish a model that an ancestral duplication of a donor TALT region to a proximal telomere region forms a genomic reservoir ready to be incorporated into telomeres on ALT activation.
- ISSN
- 2041-1723
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