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Uniform mesoporous dye-doped silica nanoparticles decorated with multiple magnetite nanocrystals for simultaneous enhanced magnetic resonance imaging, fluorescence imaging, and drug delivery

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dc.contributor.authorLee, Ji Eun-
dc.contributor.authorLee, Nohyun-
dc.contributor.authorKim, Hyoungsu-
dc.contributor.authorKim, Jaeyun-
dc.contributor.authorChoi, Seung Hong-
dc.contributor.authorKim, Jeong Hyun-
dc.contributor.authorKim, Taeho-
dc.contributor.authorSong, In Chan-
dc.contributor.authorPark, Seung Pyo-
dc.contributor.authorMoon, Woo Kyung-
dc.contributor.authorHyeon, Taeghwan-
dc.date.accessioned2020-04-27T13:19:45Z-
dc.date.available2020-04-27T13:19:45Z-
dc.date.created2020-03-18-
dc.date.issued2010-01-
dc.identifier.citationJournal of the American Chemical Society, Vol.132 No.2, pp.552-557-
dc.identifier.issn0002-7863-
dc.identifier.other92797-
dc.identifier.urihttps://hdl.handle.net/10371/165775-
dc.description.abstractHighly versatile nanocomposite nanoparticles were synthesized by decorating the surface of mesoporous dye-doped silica nanoparticles with multiple magnetite nanocrystals. The superparamagnetic property of the magnetite nanocrystals enabled the nanoparticles to be used as a contrast agent in magnetic resonance (MR) imaging, and the dye molecule in the silica framework imparted optical imaging modality. Integrating a multitude of magnetite nanocrystals on the silica surface resulted in remarkable enhancement of MR signal due to the synergistic magnetism. An anticancer drug, doxorubicin (DOX), could be loaded in the pores and induced efficient cell death. In vivo passive targeting and accumulation of the nanoparticles at the tumor sites was confirmed by both T2 MR and fluorescence imaging. Furthermore, apoptotic morphology was clearly detected in tumor tissues of mice treated with DOX loaded nanocomposite nanoparticles, demonstrating that DOX was successfully delivered to the tumor sites and its anticancer activity was retained.-
dc.language영어-
dc.publisherAmerican Chemical Society-
dc.titleUniform mesoporous dye-doped silica nanoparticles decorated with multiple magnetite nanocrystals for simultaneous enhanced magnetic resonance imaging, fluorescence imaging, and drug delivery-
dc.typeArticle-
dc.contributor.AlternativeAuthor문우경-
dc.contributor.AlternativeAuthor현택환-
dc.identifier.doi10.1021/ja905793q-
dc.citation.journaltitleJournal of the American Chemical Society-
dc.identifier.wosid000275084600030-
dc.identifier.scopusid2-s2.0-74949092822-
dc.citation.endpage557-
dc.citation.number2-
dc.citation.startpage552-
dc.citation.volume132-
dc.identifier.sci000275084600030-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorMoon, Woo Kyung-
dc.contributor.affiliatedAuthorHyeon, Taeghwan-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusMRI CONTRAST AGENTS-
dc.subject.keywordPlusRESPONSIVE CONTROLLED-RELEASE-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusQUANTUM DOTS-
dc.subject.keywordPlusINORGANIC NANOPARTICLES-
dc.subject.keywordPlusDESIGNED FABRICATION-
dc.subject.keywordPlusOXIDE NANOPARTICLES-
dc.subject.keywordPlusCANCER-THERAPY-
dc.subject.keywordPlusLIVE CELLS-
dc.subject.keywordPlusSHELL-
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