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Mitochondria-targeting ceria nanoparticles as antioxidants for Alzheimer's disease

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dc.contributor.authorKwon, Hyek Jin-
dc.contributor.authorCha, Moon-Yong-
dc.contributor.authorKim, Dokyoon-
dc.contributor.authorKim, Dong Kyu-
dc.contributor.authorSoh, Min-
dc.contributor.authorShin, Kwangsoo-
dc.contributor.authorHyeon, Taeghwan-
dc.contributor.authorMook-Jung, Inhee-
dc.date.accessioned2020-04-27T13:35:43Z-
dc.date.available2020-04-27T13:35:43Z-
dc.date.created2018-08-21-
dc.date.issued2016-02-
dc.identifier.citationACS Nano, Vol.10 No.2, pp.2860-2870-
dc.identifier.issn1936-0851-
dc.identifier.other45091-
dc.identifier.urihttps://hdl.handle.net/10371/165993-
dc.description.abstractMitochondrial oxidative stress is a key pathologic factor in neurodegenerative diseases, including Alzheimer's disease. Abnormal generation of reactive oxygen species (ROS), resulting from mitochondrial dysfunction, can lead to neuronal cell death. Ceria (CeO2) nanoparticles are known to function as strong and recyclable ROS scavengers by shuttling between Ce3+ and Ce4+ oxidation states. Consequently, targeting ceria nano particles selectively to mitochondria might be a promising therapeutic approach for neurodegenerative diseases. Here, we report the design and synthesis of triphenylphosphonium-conjugated ceria nanoparticles that localize to mitochondria and suppress neuronal death in a SXFAD transgenic Alzheimer's disease mouse model. The triphenylphosphonium-conjugated ceria nanoparticles mitigate reactive gnosis and morphological mitochondria damage observed in these mice. Altogether, our data indicate that the triphenylphosphoniuni-conjugated ceria nanoparticles are a potential therapeutic candidate for mitochondrial oxidative stress in Alzheimer's disease.-
dc.language영어-
dc.publisherAmerican Chemical Society-
dc.titleMitochondria-targeting ceria nanoparticles as antioxidants for Alzheimer's disease-
dc.typeArticle-
dc.contributor.AlternativeAuthor묵인희-
dc.contributor.AlternativeAuthor현택환-
dc.identifier.doi10.1021/acsnano.5b08045-
dc.citation.journaltitleACS Nano-
dc.identifier.wosid000370987400131-
dc.identifier.scopusid2-s2.0-84960153103-
dc.citation.endpage2870-
dc.citation.number2-
dc.citation.startpage2860-
dc.citation.volume10-
dc.identifier.sci000370987400131-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorHyeon, Taeghwan-
dc.contributor.affiliatedAuthorMook-Jung, Inhee-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusOXIDE NANOPARTICLES-
dc.subject.keywordPlusOXIDATIVE STRESS-
dc.subject.keywordPlusA-BETA-
dc.subject.keywordPlusAMYLOID-BETA-
dc.subject.keywordPlusMOUSE MODEL-
dc.subject.keywordPlusCELL-DEATH-
dc.subject.keywordPlusNEURODEGENERATION-
dc.subject.keywordPlusDYSFUNCTION-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordPlusTOXICITY-
dc.subject.keywordAuthorAlzheimer&apos-
dc.subject.keywordAuthors disease-
dc.subject.keywordAuthorceria nanoparticles-
dc.subject.keywordAuthormitochondria-
dc.subject.keywordAuthorreactive oxygen species-
dc.subject.keywordAuthortherapeutic agents-
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