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Rapid Hepatobiliary Excretion of Micelle-Encapsulated/Radiolabeled Upconverting Nanoparticles as an Integrated Form

Cited 20 time in Web of Science Cited 16 time in Scopus
Authors
Seo, Hyo Jung; Nam, Sang Hwan; Im, Hyung-Jun; Park, Ji-Yong; Lee, Ji Youn; Yoo, Byeongjun; Lee, Yun-Sang; Jeong, Jae Min; Hyeon, Taeghwan; Kim, Ji Who; Lee, Jae Sung; Jang, In-Jin; Cho, Joo-Youn; Hwang, Do Won; Suh, Yung Doug; Lee, Dong Soo
Issue Date
2015-10
Citation
Scientific Reports, Vol.5, p. 15685
Abstract
In the field of nanomedicine, long term accumulation of nanoparticles (NPs) in the mononuclear phagocyte system (MPS) such as liver is the major hurdle in clinical translation. On the other hand, NPs could be excreted via hepatobiliary excretion pathway without overt tissue toxicity. Therefore, it is critical to develop NPs that show favorable excretion property. Herein, we demonstrated that micelle encapsulated Cu-64-labeled upconverting nanoparticles (micelle encapsulated Cu-64-NOTA-UCNPs) showed substantial hepatobiliary excretion by in vivo positron emission tomography (PET) and also upconversion luminescence imaging (ULI). Ex vivo biodistribution study reinforced the imaging results by showing clearance of 84% of initial hepatic uptake in 72 hours. Hepatobiliary excretion of the UCNPs was also verified by transmission electron microscopy (TEM) examination. Micelle encapsulated Cu-64-NOTA-UCNPs could be an optimal bimodal imaging agent owing to quantifiability of Cu-64, ability of in vivo/ex vivo ULI and good hepatobiliary excretion property.
ISSN
2045-2322
URI
http://hdl.handle.net/10371/166022
DOI
https://doi.org/10.1038/srep15685
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Chemical Convergence for Energy and Environment (에너지환경 화학융합기술전공)Journal Papers (저널논문_에너지환경 화학융합기술전공)
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