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High-resolution three-photon biomedical imaging using doped ZnS nanocrystals

Cited 162 time in Web of Science Cited 183 time in Scopus
Authors
Yu, Jung Ho; Kwon, Seung-Hae; Petrasek, Zdenek; Park, Ok Kyu; Jun, Samuel Woojoo; Shin, Kwangsoo; Choi, Moonkee; Park, Yong Il; Park, Kyeongsoon; Na, Hyon Bin; Lee, Nohyun; Lee, Dong Won; Kim, Jeong Hyun; Schwille, Petra; Hyeon, Taeghwan
Issue Date
2013-04
Citation
Nature Materials, Vol.12 No.4, pp.359-366
Abstract
Three-photon excitation is a process that occurs when three photons are simultaneously absorbed within a luminophore for photo-excitation through virtual states. Although the imaging application of this process was proposed decades ago, three-photon biomedical imaging has not been realized yet owing to its intrinsic low quantum efficiency. We herein report on high-resolution in vitro and in vivo imaging by combining three-photon excitation of ZnS nanocrystals and visible emission from Mn2+ dopants. The large three-photon cross-section of the nanocrystals enabled targeted cellular imaging under high spatial resolution, approaching the theoretical limit of three-photon excitation. Owing to the enhanced Stokes shift achieved through nanocrystal doping, the three-photon process was successfully applied to high-resolution in vivo tumour-targeted imaging. Furthermore, the biocompatibility of ZnS nanocrystals offers great potential for clinical applications of three-photon imaging.
ISSN
1476-1122
URI
http://hdl.handle.net/10371/166167
DOI
https://doi.org/10.1038/NMAT3565
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Chemical Convergence for Energy and Environment (에너지환경 화학융합기술전공)Journal Papers (저널논문_에너지환경 화학융합기술전공)
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