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Theranostic Probe Based on Lanthanide-Doped Nanoparticles for Simultaneous In Vivo Dual-Modal Imaging and Photodynamic Therapy

Cited 289 time in Web of Science Cited 308 time in Scopus
Authors
Park, Yong Il; Kim, Hyung Min; Kim, Jeong Hyun; Moon, Kyung Chul; Yoo, Byeongjun; Lee, Kang Taek; Lee, Nohyun; Choi, Yoonseok; Park, Wooram; Ling, Daishun; Na, Kun; Moon, Woo Kyung; Choi, Seung Hong; Park, Hong Seok; Yoon, Soo-Young; Suh, Yung Doug; Lee, Sung Ho; Hyeon, Taeghwan
Issue Date
2012-11
Citation
Advanced Materials, Vol.24 No.42, pp.5755-5761
Keywords
luminescencemagnetic resonance imagingnanoparticlesphotodynamic therapyupconversion
Abstract
Dual-modal in vivo tumor imaging and photodynamic therapy using hexagonal NaYF4:Yb,Er/NaGdF4 core-shell upconverting nanoparticles combined with a photosensitizer, chlorin e6, is reported. Tumors can be clearly observed not only in the upconversion luminescence image but also in the magnetic resonance image. In vivo photodynamic therapy by systemic administration is demonstrated under 980 nm irradiation.
ISSN
0935-9648
URI
http://hdl.handle.net/10371/166184
DOI
https://doi.org/10.1002/adma.201202433
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Chemical Convergence for Energy and Environment (에너지환경 화학융합기술전공)Journal Papers (저널논문_에너지환경 화학융합기술전공)
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