Ceria nanoparticles that can protect against ischemic stroke

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Ceria nanoparticles that can protect against ischemic stroke

Cited 419 time in Web of Science Cited 458 time in Scopus

Authors: Kim, Chi Kyung; Kim, Taeho; Choi, In-Young; Soh, Min; Kim, Dohoung; Kim, Young-Ju; Jang, Hyunduk; Yang, Hye-Sung; Kim, Jun Yup; Park, Hong-Kyun; Park, Seung Pyo; Park, Sangseung; Yu, Taekyung; Yoon, Byung-Woo; Lee, Seung-Hoon; Hyeon, Taeghwan

Citation: Angewandte Chemie - International Edition, Vol.51 No.44, pp.11039-11043

Abstract: Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.