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Water-dispersible ferrimagnetic iron oxide nanocubes with extremely high r 2 relaxivity for highly sensitive in vivo MRI of tumors
Cited 248 time in
Web of Science
Cited 263 time in Scopus
- Authors
- Issue Date
- 2012-06
- Publisher
- American Chemical Society
- Citation
- Nano Letters, Vol.12 No.6, pp.3127-3131
- Abstract
- The theoretically predicted maximum r(2) relaxivity of iron oxide nanoparticles was achieved by optimizing the overall size of ferrimagnetic iron oxide nanocubes. Uniform-sized iron oxide nanocubes with an edge length of 22 nm, encapsulated with PEG-phospholipids (WFION), exhibited high colloidal stability in aqueous media. In addition, WFIONs are biocompatible and did not affect cell viability at concentrations up to 0.75 mg Fe/ml. Owing to the enhanced colloidal stability and the high r(2) relaxivity (761 mM(-1) s(-1)), it was possible to successfully perform in vivo MR imaging of tumors by intravenous injection of 22-nm-sized WFIONs, using a clinical 3-T MR scanner.
- ISSN
- 1530-6984
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