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Magnetosome-like ferrimagnetic iron oxide nanocubes for highly sensitive MRI of single cells and transplanted pancreatic islets
DC Field | Value | Language |
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dc.contributor.author | Lee, Nohyun | - |
dc.contributor.author | Kim, Hyoungsu | - |
dc.contributor.author | Choi, Seung Hong | - |
dc.contributor.author | Park, Mihyun | - |
dc.contributor.author | Kim, Dokyoon | - |
dc.contributor.author | Kim, Hyo-Cheol | - |
dc.contributor.author | Choi, Yoonseok | - |
dc.contributor.author | Lin, Shunmei | - |
dc.contributor.author | Kim, Byung Hyo | - |
dc.contributor.author | Jung, Hye Seung | - |
dc.contributor.author | Kim, Hyeonjin | - |
dc.contributor.author | Park, Kyong Soo | - |
dc.contributor.author | Moon, Woo Kyung | - |
dc.contributor.author | Hyeon, Taeghwan | - |
dc.date.accessioned | 2020-04-27T13:55:40Z | - |
dc.date.available | 2020-04-27T13:55:40Z | - |
dc.date.created | 2020-03-18 | - |
dc.date.issued | 2011-02 | - |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the United States of America, Vol.108 No.7, pp.2662-2667 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.other | 92766 | - |
dc.identifier.uri | https://hdl.handle.net/10371/166230 | - |
dc.description.abstract | For ultrasensitive magnetic resonance imaging (MRI), magnetic nanoparticles with extremely high r2 relaxivity are strongly desired. Magnetosome-like nanoparticles were prepared by coating polyethylene glycol-phospholipid (PEG-phospholipid) onto ferrimagnetic iron oxide nanocubes (FIONs). FIONs exhibited a very high relaxivity (r2) of 324 mM(-1) s(-1), allowing efficient labeling of various kinds of cells. The magnetic resonance (MR) imaging of single cells labeled with FIONs is demonstrated not only in vitro but also in vivo. Pancreatic islet grafts and their rejection could be imaged using FIONs on a 1.5 T clinical MRI scanner. The strong contrast effect of FIONs enabled MR imaging of transplanted islets in small rodents as well as in large animals. Therefore, we expect that MR imaging of pancreatic islet grafts using FIONs has the potentials for clinical applications. Furthermore, FIONs will enable highly sensitive noninvasive assessment after cell transplantation. | - |
dc.language | 영어 | - |
dc.publisher | National Academy of Sciences | - |
dc.title | Magnetosome-like ferrimagnetic iron oxide nanocubes for highly sensitive MRI of single cells and transplanted pancreatic islets | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김현진 | - |
dc.contributor.AlternativeAuthor | 문우경 | - |
dc.contributor.AlternativeAuthor | 박경수 | - |
dc.contributor.AlternativeAuthor | 현택환 | - |
dc.identifier.doi | 10.1073/pnas.1016409108 | - |
dc.citation.journaltitle | Proceedings of the National Academy of Sciences of the United States of America | - |
dc.identifier.wosid | 000287377000012 | - |
dc.identifier.scopusid | 2-s2.0-79952613531 | - |
dc.citation.endpage | 2667 | - |
dc.citation.number | 7 | - |
dc.citation.startpage | 2662 | - |
dc.citation.volume | 108 | - |
dc.identifier.sci | 000287377000012 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Hyeonjin | - |
dc.contributor.affiliatedAuthor | Park, Kyong Soo | - |
dc.contributor.affiliatedAuthor | Moon, Woo Kyung | - |
dc.contributor.affiliatedAuthor | Hyeon, Taeghwan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MULTIFUNCTIONAL MAGNETIC NANOPARTICLES | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | BIOMEDICAL APPLICATIONS | - |
dc.subject.keywordPlus | SHELL NANOPARTICLES | - |
dc.subject.keywordPlus | TARGETED DELIVERY | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | CONTRAST | - |
dc.subject.keywordPlus | AGENTS | - |
dc.subject.keywordPlus | PARTICLES | - |
dc.subject.keywordPlus | TRACKING | - |
dc.subject.keywordAuthor | cell tracking | - |
dc.subject.keywordAuthor | contrast agent | - |
dc.subject.keywordAuthor | molecular imaging | - |
dc.subject.keywordAuthor | diabetes | - |
dc.subject.keywordAuthor | islet transplantation | - |
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