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Asian Thoracic Oncology Research Group Expert Consensus Statement on Optimal Management of Stage III NSCLC

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Authors
Tan, Wan Ling; Chua, Kevin L. M.; Lin, Chia-Chi; Lee, Victor H. F.; Tho, Lye Mun; Chan, Anthony W.; Ho, Gwo Fuang; Reungwetwattana, Thanyanan; Yang, James C.; Kim, Dong-Wan; Soo, Ross A.; Ahn, Yong Chan; Onishi, Hiroshi; Ahn, Myung-Ju; Mok, Tony S. K.; Tan, Daniel S. W.; Yang, Fan
Issue Date
2020-03
Citation
Journal of Thoracic Oncology, Vol.15 No.3, pp.324-343
Keywords
AsianConsensus statementStage III NSCLC
Abstract
Stage III NSCLC represents a heterogeneous disease for which optimal treatment continues to pose a clinical challenge. Recent changes in the American Joint Commission on Cancer staging to the eighth edition has led to a shift in TNM stage grouping and redefined the subcategories (IIIA-C) in stage III NSCLC for better prognostication. Although concurrent chemoradiotherapy has remained standard-of-care for stage III NSCLC for almost 2 decades, contemporary considerations include the impact of different molecular subsets of NSCLC, and the roles of tyrosine kinase inhibitors post-definitive therapy and of immune checkpoint inhibitors following chemoradiotherapy. With rapid evolution of diagnostic algorithms and expanding treatment options, the need for interdisciplinary input involving multiple specialists (medical oncologists, radiation oncologists, pulmonologists, radiologists, pathologists and thoracic surgeons) has become increasingly important. The unique demographics of Asian NSCLC pose further challenges when applying clinical trial data into clinical practice. This includes differences in smoking rates, prevalence of oncogenic driver mutations, and access to health care resources including molecular testing, prompting the need for critical review of existing data and identification of current gaps. In this expert consensus statement by the Asian Thoracic Oncology Research Group, an interdisciplinary group of experts representing Hong Kong, Korea, Japan, Taiwan, Singapore, Thailand, Malaysia, and Mainland China was convened. Standard clinical practices for stage III NSCLC across different Asian countries were discussed from initial diagnosis and staging through to multi-modality approaches including surgery, chemotherapy, radiation, targeted therapies, and immunotherapy. (C) 2019 Published by Elsevier Inc. on behalf of International Association for the Study of Lung Cancer.
ISSN
1556-0864
URI
http://hdl.handle.net/10371/166247
DOI
https://doi.org/10.1016/j.jtho.2019.10.022
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College of Medicine/School of Medicine (의과대학/대학원)Cancer Research Institute (암연구소)Journal Papers (저널논문_암연구소)
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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