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액상 색전 물질의 접착성을 조절하기 위한 불소화 시아노 아크릴레이트 디자인 : Design of Fluorinated Cyanoacrylates to Control Adhesiveness of Liquid Embolic Materials

DC Field Value Language
dc.contributor.advisor안철희-
dc.contributor.author조창현-
dc.date.accessioned2020-05-07T03:39:14Z-
dc.date.available2020-05-07T03:39:14Z-
dc.date.issued2020-
dc.identifier.other000000158683-
dc.identifier.urihttp://dcollection.snu.ac.kr/common/orgView/000000158683ko_KR
dc.description학위논문(석사)--서울대학교 대학원 :공과대학 재료공학부,2020. 2. 안철희.-
dc.description.abstractEmbolotherapy is a method of inserting a catheter into the body to block the vessel or necrosis the tissue by infusion of an embolic materials. Embolic materials are classified according to the location of the lesion of vessel or the disease. Cyanoacrylate, one of the liquid embolic materials, is used in clinic with tantalum powder or oil with radiopacity. In order to improve this, in the previous study, the cyanoacrylate which have radiopacity was designed and synthesized. This new cyanoacrylate monomer has a problem that polymerization of cyanoacrylate monomer is decreased when oil is added to reduce adhesiveness.
To improve this, various fluorinated cyanoacrylates were designed and three monomer ( named F, CF, FF) were synthesized according to the fluorine content and carbon chain length of side group. The polymerization rate and adhesiveness of mixture of monomer and oil with ratio 1:0 to 1:3 were measured and compared Histoacryl® which already used in clinical purpose.
As a result, it was confirmed that the polymerization rate was accelerated as fluorine content was increased. In addition, the polymerization rate of monomer FF ,the monomer with highest fluorine content among three monomers, was not as slow as the other monomer when oil is added. And at the same time, the adhesiveness was decreased with similar amount of other monomers.
In conclusion, mixture of monomer FF and oil has fastest polymerization rate and similar adhesiveness with other monomers. Through it is expected to be used as a replaced cyanoacrylate in composition in previous study.
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dc.description.tableofcontents1. 서론 1
2. 실험 방법 6
2.1. 불소화 시아노 아크릴레이트의 합성 6
2.2.1. 모노머 F, CF의 합성 6
2.2.2. 모노머 FF의 합성 6
2.2. In vitro 중합 속도 실험 9
2.3. In vitro 접착력 실험 11
3. 실험 결과 및 고찰 13
3.1. 디프로텍션 조건 최적화 13
3.2. 불소화 모노머의 특성 16
3.3. In vitro 중합 속도 실험 16
3.4. In vitro 접착력 실험 22
4. 결론 25
5. 참고문헌 28
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dc.language.isokor-
dc.publisher서울대학교 대학원-
dc.subject.ddc620.1-
dc.title액상 색전 물질의 접착성을 조절하기 위한 불소화 시아노 아크릴레이트 디자인-
dc.title.alternativeDesign of Fluorinated Cyanoacrylates to Control Adhesiveness of Liquid Embolic Materials-
dc.typeThesis-
dc.typeDissertation-
dc.contributor.department공과대학 재료공학부-
dc.description.degreeMaster-
dc.date.awarded2020-02-
dc.identifier.uciI804:11032-000000158683-
dc.identifier.holdings000000000042▲000000000044▲000000158683▲-
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