Short term effects of topical cyclosporine and viscoelastic on the ocular surfaces in patients with dry eye

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Moon, Jun Woong; Lee, Hyun Joo; Shin, Ki Chul; Wee, Won Ryang; Lee, Jin Hak; Kim, Mee Kum
Issue Date
Korean Journal of Ophthalmology
Korean J Ophthalmol. 2007 Dec;21(4):189-94.
Adjuvants, Immunologic/administration & dosageAdministration, TopicalCell CountChondroitin Sulfates/*administration & dosageConjunctiva/drug effects/pathologyCyclosporine/*administration & dosageDrug Administration ScheduleDrug CombinationsDrug Therapy, CombinationDry Eye Syndromes/*drug therapy/metabolism/pathologyEpithelium/drug effects/pathologyFemaleFollow-Up StudiesGoblet Cells/drug effects/pathologyHumansHyaluronic Acid/*administration & dosageImmunosuppressive Agents/*administration & dosageMaleMiddle AgedOphthalmic Solutions/administration & dosageTears/drug effects/metabolismTime FactorsTreatment Outcome
PURPOSE: To compare the short term effects of topical 0.05% cyclosporine (CsA) and a mixture of 0.08% chondroitin sulfate and 0.06% sodium hyaluronate (CS-HA) on dry eye ocular surfaces. METHODS: 36 patients with moderate to severe dry eye (5 mm/5 min or less with Schirmer's test or tear break up time (BUT) less than 6 seconds), were treated with topical application of CS-HA on one eye and CsA on the other 4 times a day for 6-8 weeks. BUT, Schirmer's test without anesthesia, and conjunctival impression cytology (CIC; goblet cell density, nucleus to cytoplasmic ratio, and epithelial cell morphology) were evaluated and compared between eyes before and after treatment (repeated measurement of ANOVA). RESULTS: After treatment, BUT and tear wettings were significantly prolonged in each group. Topical CsA treated eyes had greater increase in BUT (p=0.026); there was no significant difference in tear wetting (p=0.132). While the 3 parameters of CIC improved in both groups, goblet cell density was significantly higher in eyes treated with CsA (p=0.033). CONCLUSIONS: While both CS-HA and 0.05% CsA eyedrops improve ocular surfaces, topical CsA may have a better effect on enhancing tear film stability and goblet cell density.
1011-8942 (Print)
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College of Medicine/School of Medicine (의과대학/대학원)Ophthalmology (안과학전공)Journal Papers (저널논문_안과학전공)
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