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Short term effects of topical cyclosporine and viscoelastic on the ocular surfaces in patients with dry eye
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Moon, Jun Woong | - |
dc.contributor.author | Lee, Hyun Joo | - |
dc.contributor.author | Shin, Ki Chul | - |
dc.contributor.author | Wee, Won Ryang | - |
dc.contributor.author | Lee, Jin Hak | - |
dc.contributor.author | Kim, Mee Kum | - |
dc.date.accessioned | 2009-11-27T07:50:09Z | - |
dc.date.available | 2009-11-27T07:50:09Z | - |
dc.date.issued | 2007-12-08 | - |
dc.identifier.citation | Korean J Ophthalmol. 2007 Dec;21(4):189-94. | en |
dc.identifier.issn | 1011-8942 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18063881 | - |
dc.identifier.uri | https://hdl.handle.net/10371/16815 | - |
dc.description.abstract | PURPOSE: To compare the short term effects of topical 0.05% cyclosporine (CsA) and a mixture of 0.08% chondroitin sulfate and 0.06% sodium hyaluronate (CS-HA) on dry eye ocular surfaces. METHODS: 36 patients with moderate to severe dry eye (5 mm/5 min or less with Schirmer's test or tear break up time (BUT) less than 6 seconds), were treated with topical application of CS-HA on one eye and CsA on the other 4 times a day for 6-8 weeks. BUT, Schirmer's test without anesthesia, and conjunctival impression cytology (CIC; goblet cell density, nucleus to cytoplasmic ratio, and epithelial cell morphology) were evaluated and compared between eyes before and after treatment (repeated measurement of ANOVA). RESULTS: After treatment, BUT and tear wettings were significantly prolonged in each group. Topical CsA treated eyes had greater increase in BUT (p=0.026); there was no significant difference in tear wetting (p=0.132). While the 3 parameters of CIC improved in both groups, goblet cell density was significantly higher in eyes treated with CsA (p=0.033). CONCLUSIONS: While both CS-HA and 0.05% CsA eyedrops improve ocular surfaces, topical CsA may have a better effect on enhancing tear film stability and goblet cell density. | en |
dc.language.iso | en | - |
dc.publisher | Korean Journal of Ophthalmology | en |
dc.subject | Adjuvants, Immunologic/administration & dosage | en |
dc.subject | Administration, Topical | en |
dc.subject | Cell Count | en |
dc.subject | Chondroitin Sulfates/*administration & dosage | en |
dc.subject | Conjunctiva/drug effects/pathology | en |
dc.subject | Cyclosporine/*administration & dosage | en |
dc.subject | Drug Administration Schedule | en |
dc.subject | Drug Combinations | en |
dc.subject | Drug Therapy, Combination | en |
dc.subject | Dry Eye Syndromes/*drug therapy/metabolism/pathology | en |
dc.subject | Epithelium/drug effects/pathology | en |
dc.subject | Female | en |
dc.subject | Follow-Up Studies | en |
dc.subject | Goblet Cells/drug effects/pathology | en |
dc.subject | Humans | en |
dc.subject | Hyaluronic Acid/*administration & dosage | en |
dc.subject | Immunosuppressive Agents/*administration & dosage | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Ophthalmic Solutions/administration & dosage | en |
dc.subject | Tears/drug effects/metabolism | en |
dc.subject | Time Factors | en |
dc.subject | Treatment Outcome | en |
dc.title | Short term effects of topical cyclosporine and viscoelastic on the ocular surfaces in patients with dry eye | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 문준웅 | - |
dc.contributor.AlternativeAuthor | 이현주 | - |
dc.contributor.AlternativeAuthor | 신기철 | - |
dc.contributor.AlternativeAuthor | 위원량 | - |
dc.contributor.AlternativeAuthor | 이진학 | - |
dc.contributor.AlternativeAuthor | 김미금 | - |
dc.identifier.doi | 10.3341/kjo.2007.21.4.189 | - |
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