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A differential risk assessment and decision model for Transarterial chemoembolization in hepatocellular carcinoma based on hepatic function
DC Field | Value | Language |
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dc.contributor.author | Nam, Joon Yeul | - |
dc.contributor.author | Choe, A Reum | - |
dc.contributor.author | Sinn, Dong Hyun | - |
dc.contributor.author | Lee, Jeong-Hoon | - |
dc.contributor.author | Kim, Hwi Young | - |
dc.contributor.author | Yu, Su Jong | - |
dc.contributor.author | Kim, Yoon Jun | - |
dc.contributor.author | Yoon, Jung-Hwan | - |
dc.contributor.author | Lee, Jeong Min | - |
dc.contributor.author | Chung, Jin Wook | - |
dc.contributor.author | Choi, Sun Young | - |
dc.contributor.author | Lee, Jeong Kyong | - |
dc.contributor.author | Baek, Seung Yon | - |
dc.contributor.author | Lee, Hye Ah | - |
dc.contributor.author | Kim, Tae Hun | - |
dc.contributor.author | Yoo, Kwon | - |
dc.date.accessioned | 2020-07-13T06:31:01Z | - |
dc.date.available | 2020-07-13T15:31:55Z | - |
dc.date.issued | 2020-06-01 | - |
dc.identifier.citation | BMC Cancer. 2020 Jun 01;20(1):504 | ko_KR |
dc.identifier.issn | 1471-2407 | - |
dc.identifier.uri | https://hdl.handle.net/10371/168585 | - |
dc.description.abstract | Background
The decision of transarterial chemoembolization (TACE) initiation and/or repetition remains challenging in patients with unresectable hepatocellular carcinoma (HCC). The aim was to develop a prognostic scoring system to guide TACE initiation/repetition. Methods A total of 597 consecutive patients who underwent TACE as their initial treatment for unresectable HCC were included. We derived a prediction model using independent risk factors for overall survival (OS), which was externally validated in an independent cohort (n = 739). Results Independent risk factors of OS included Albumin-bilirubin (ALBI) grade, maximal tumor size, alpha-fetoprotein, and tumor response to initial TACE, which were used to develop a scoring system (ASAR). C-index values for OS were 0.733 (95% confidence interval [CI] = 0.570–0.871) in the derivation, 0.700 (95% CI = 0.445–0.905) in the internal validation, and 0.680 (95% CI = 0.652–0.707) in the external validation, respectively. Patients with ASAR< 4 showed significantly longer OS than patients with ASAR≥4 in all three datasets (all P < 0.001). Among Child-Pugh class B patients, a modified model without TACE response, i.e., ASA(R), discriminated OS with a c-index of 0.788 (95% CI, 0.703–0.876) in the derivation, and 0.745 (95% CI, 0.646–0.862) in the internal validation, and 0.670 (95% CI, 0.605–0.725) in the external validation, respectively. Child-Pugh B patients with ASA(R) < 4 showed significantly longer OS than patients with ASA(R) ≥ 4 in all three datasets (all P < 0.001). Conclusions ASAR provides refined prognostication for repetition of TACE in patients with unresectable HCC. For Child-Pugh class B patients, a modified model with baseline factors might guide TACE initiation. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.title | A differential risk assessment and decision model for Transarterial chemoembolization in hepatocellular carcinoma based on hepatic function | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 남준열 | - |
dc.contributor.AlternativeAuthor | 최아름 | - |
dc.contributor.AlternativeAuthor | 신동현 | - |
dc.contributor.AlternativeAuthor | 이정훈 | - |
dc.contributor.AlternativeAuthor | 김휘영 | - |
dc.contributor.AlternativeAuthor | 유수종 | - |
dc.contributor.AlternativeAuthor | 김윤준 | - |
dc.contributor.AlternativeAuthor | 윤정환 | - |
dc.contributor.AlternativeAuthor | 이정민 | - |
dc.contributor.AlternativeAuthor | 정진욱 | - |
dc.contributor.AlternativeAuthor | 최선영 | - |
dc.contributor.AlternativeAuthor | 이정경 | - |
dc.contributor.AlternativeAuthor | 백승연 | - |
dc.contributor.AlternativeAuthor | 이혜아 | - |
dc.contributor.AlternativeAuthor | 김태훈 | - |
dc.contributor.AlternativeAuthor | 유권 | - |
dc.identifier.doi | 10.1186/s12885-020-06975-2 | - |
dc.citation.journaltitle | BMC Cancer | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2020-06-16T09:31:52Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 504 | ko_KR |
dc.citation.volume | 20 | ko_KR |
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