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Pharmacokinetics of 5-[2-propyloxy-5-(1-methy1-2-pyrollidinylethylamidosulphonyl)phenyl]-1-methyl-3-propyl-1, 6-dihydro-7H-pyrazolo(4,3-d)pyrimidine-7-one), a new phosphodiesterase type V inhibitor : 새로운 포스포디에스터라제 V 저해제, 5-[2-propyloxy-5-(1-methyl-2-pyrollidinylethylamidosulphony1)phenyl]-1-methyl-3-propyl-1, 6-dihydro-7H-pyrazolo(4,3-d)pyrimidine-7-one)의 약물역학에 관한 연구
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- Authors
- Advisor
- 이명걸
- Issue Date
- 2005
- Publisher
- 서울대학교 대학원
- Keywords
- DA-8159 ; DA-8159 ; DA-8164 ; DA-8164 ; 고속액체크로마토그라피 ; High performance liquid chromatography ; 안정성 ; Stability ; 혈액분배 ; Blood partition ; 단백결합 ; Protein binding ; 약물역학 ; Pharmacokinetics ; 간 및 소장 초회통과효과 ; Hepatic and intestinal first pass effects ; 대사효소 유도제 및 저해제 ; Enzyme inducers and inhibitors ; 독성동태학 ; Toxicokinetics ; 종간 차이 ; Species differences ; animal scale-up ; Interspecies scaling ; 단백질-칼로리영양결핍 랫드 ; Protein calorie malnutrition ; uranyl nitrate로 유도한 급성신부전 랫드 ; Uranyl nitrate-induced acute renal failure.
- Description
- Thesis(doctoral)--서울대학교 대학원 :약학과 약물학전공,2005.
- Language
- English
- URI
- http://dcollection.snu.ac.kr:80/jsp/common/DcLoOrgPer.jsp?sItemId=000000050002
https://hdl.handle.net/10371/17536
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