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Surgical outcome and prognostic factors of cryptogenic neocortical epilepsy

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Authors
Lee, Sang Kun; Lee, Seo Young; Kim, Kwang-Ki; Hong, Kkeun-Sik; Lee, Dong-Soo; Chung, Chun-Kee
Issue Date
2005-07-23
Publisher
Little Brown and Co
Citation
Ann Neurol. 2005 Oct;58(4):525-32.
Keywords
AdolescentAdultChildDisease ProgressionElectroencephalography/methodsEpilepsy/pathology/physiopathology/*surgeryFemaleFollow-Up StudiesHumansMaleMiddle AgedNeurosurgery/*methodsPositron-Emission TomographyRetrospective StudiesTechnetium Tc 99m ExametazimeTomography, Emission-Computed, Single-Photon*Treatment Outcome
Abstract
Surgical treatment of cryptogenic neocortical epilepsy is challenging. The aim of this study was to evaluate surgical outcomes and to identify possible prognostic factors including the results of various diagnostic tools. Eighty-nine patients with neocortical epilepsy with normal magnetic resonance imaging (35 patients with frontal lobe epilepsy, 31 with neocortical temporal lobe epilepsy, 11 with occipital lobe epilepsy, 11 with parietal lobe epilepsy, and 1 with multifocal epilepsy) underwent invasive study and focal surgical resection. Patients were observed for at least 2 years after surgery. The localizing values of interictal electroencephalogram (EEG), ictal scalp EEG, interictal 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), and subtraction ictal single-photon emission computed tomography were evaluated. Seventy-one patients (80.0%) had a good surgical outcome (Engel class 1-3); 42 patients were seizure free. Diagnostic sensitivities of interictal EEG, ictal scalp EEG, FDG-PET, and subtraction ictal single-photon emission computed tomography were 37.1%, 70.8%, 44.3%, and 41.1%, respectively. Localization by FDG-PET and interictal EEG was correlated with a seizure-free outcome. The localizing value of FDG-PET was greatest in neocortical temporal lobe epilepsy. The focalization of ictal onset and also ictal onset frequency in invasive studies were not related to surgical outcome. Concordance with two or more presurgical evaluations was significantly related to a seizure-free outcome.
ISSN
0364-5134 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16037972

http://hdl.handle.net/10371/20235
DOI
https://doi.org/10.1002/ana.20569
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College of Medicine/School of Medicine (의과대학/대학원)Neurosurgery (신경외과학전공)Journal Papers (저널논문_신경외과학전공)
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