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The potent protective effect of wild ginseng (Panax ginseng C.A. Meyer) against benzo[alpha]pyrene-induced toxicity through metabolic regulation of CYP1A1 and GSTs

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dc.contributor.authorGum, Sang Il-
dc.contributor.authorJo, Sung Jun-
dc.contributor.authorAhn, Sang Hyun-
dc.contributor.authorKim, Sang Geon-
dc.contributor.authorKim, Jin-Taek-
dc.contributor.authorShin, Heung Mook-
dc.contributor.authorCho, Min Kyung-
dc.date.accessioned2009-12-18T05:57:06Z-
dc.date.available2009-12-18T05:57:06Z-
dc.date.issued2007-06-26-
dc.identifier.citationJ Ethnopharmacol. 2007 Jul 25;112(3):568-76. Epub 2007 May 18.en
dc.identifier.issn0378-8741 (Print)-
dc.identifier.urihttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8D-4NS0KS5-2&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=90c72d3f669829d3f07dc1a67dd82cee-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17590295-
dc.identifier.urihttp://hdl.handle.net/10371/21379-
dc.description.abstractWild Panax ginseng C.A. Meyer (WG) is a well-known medicinal herb. In this study, the protective effects of a water extract from the root of WG on benzo[alpha]pyrene (BP)-induced hepatotoxicity and the mechanism of these effects were investigated for the first time. The effects of WG on liver toxicities induced by BP were assessed by blood biochemical and histopathological analyses. BP caused severe liver injury in rats, as indicated by elevated plasma ALT, AST and LPO levels. Pretreatment with WG for 4 weeks completely abrogated increases in the ALT, AST and LPO levels when challenged with BP. Reductions in GSH content and GST activity by BP were reversed by WG. These protective effects of WG against BP-induced toxicity were consistent with the results of histopathological examinations. We next examined the effects of WG on the gene expression of the enzymes that metabolize BP in H4IIE cells. CYP1A1 mRNA and protein expression were increased by BP. WG moderately inhibited BP-induced CYP1A1 gene expression. Moreover, GSTA2, GSTA3 and GSTM2 gene expressions were significantly increased by WG through the Nrf2/antioxidant responsive element pathway for enzyme induction. In summary, WG is efficacious in protecting against BP-induced hepatotoxicity as results of metabolic regulations through both the inhibition of metabolic enzyme activation and the enhancement of electrophilic detoxification, implying that WG should be considered a potential chemopreventive agent.en
dc.language.isoen-
dc.publisherElsevieren
dc.subjectAdministration, Oralen
dc.subjectAlanine Transaminase/blooden
dc.subjectAnimalsen
dc.subjectAspartate Aminotransferases/blooden
dc.subjectBenzo(a)pyrene/administration & dosage/toxicityen
dc.subjectBlotting, Westernen
dc.subjectCell Lineen
dc.subjectCytochrome P-450 CYP1A1/*genetics/metabolismen
dc.subjectGene Expression/drug effectsen
dc.subjectGlutathione Transferase/*genetics/metabolismen
dc.subjectInjections, Intraperitonealen
dc.subjectIsoenzymes/genetics/metabolismen
dc.subjectLipid Peroxidation/drug effectsen
dc.subjectLiver/drug effects/metabolism/pathologyen
dc.subjectLiver Diseases/chemically induced/enzymology/*prevention & controlen
dc.subjectMetabolic Networks and Pathways/drug effectsen
dc.subjectPanax/*chemistryen
dc.subjectPlant Extracts/administration & dosage/chemistry/*pharmacologyen
dc.subjectPlant Roots/chemistryen
dc.subjectRNA, Messenger/genetics/metabolismen
dc.subjectRatsen
dc.subjectRats, Sprague-Dawleyen
dc.subjectReverse Transcriptase Polymerase Chain Reactionen
dc.titleThe potent protective effect of wild ginseng (Panax ginseng C.A. Meyer) against benzo[alpha]pyrene-induced toxicity through metabolic regulation of CYP1A1 and GSTsen
dc.typeArticleen
dc.contributor.AlternativeAuthor안상현-
dc.contributor.AlternativeAuthor김상건-
dc.contributor.AlternativeAuthor김진택-
dc.contributor.AlternativeAuthor신흥묵-
dc.contributor.AlternativeAuthor조민경-
dc.identifier.doi10.1016/j.jep.2007.05.014-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Program in Clinical Pharmacology (협동과정-임상약리학전공)Journal Papers (저널논문_협동과정-임상약리학전공)
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