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Prognostic significance of asymptomatic coronary artery disease in patients with diabetes and need for early revascularization therapy

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dc.contributor.authorChoi, E-K-
dc.contributor.authorKoo, B-K-
dc.contributor.authorKim, H-S-
dc.contributor.authorCho, Y-M-
dc.contributor.authorKang, H-J-
dc.contributor.authorCho, Y-S-
dc.contributor.authorChung, W-Y-
dc.contributor.authorChae, I-H-
dc.contributor.authorChoi, D-J-
dc.contributor.authorOh, B-H-
dc.contributor.authorPark, Y-B-
dc.contributor.authorChoi, Y-S-
dc.date.accessioned2009-12-23T06:08:28Z-
dc.date.available2009-12-23T06:08:28Z-
dc.date.issued2007-05-19-
dc.identifier.citationDiabet Med. 2007 Sep;24(9):1003-11. Epub 2007 May 17.en
dc.identifier.issn0742-3071 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17509072-
dc.identifier.urihttp://hdl.handle.net/10371/22156-
dc.description.abstractAIMS: Information on the clinical outcome of patients with diabetes with silent myocardial ischaemia is limited. We compared the clinical and angiographic characteristics, and the clinical outcomes of diabetic patients with asymptomatic or symptomatic coronary artery disease (CAD). METHODS: Three hundred and ten consecutive diabetic patients with CAD were divided into two groups according to the presence of angina and followed for a mean of 5 years. Fifty-six asymptomatic patients with a positive stress test and CAD on coronary angiography were compared with 254 symptomatic patients, 167 with unstable angina and 87 with chronic stable angina. RESULTS: Although the severity of coronary atherosclerosis was similar in asymptomatic and symptomatic patients, revascularization therapy was performed less frequently in the asymptomatic than the symptomatic patients (26.8 vs. 62.0%; P < 0.001). Asymptomatic patients experienced a similar number of major adverse cardiac events (MACEs; death, non-fatal myocardial infarction, and revascularization; 32 vs. 28%; P = 0.57), but had higher cardiac mortality than symptomatic patients (26 vs. 9%; P < 0.001). However, patients who underwent revascularization therapy at the time of CAD diagnosis in these two groups showed similar MACE and cardiac mortality (20.0 vs. 22.5%, 6.7 vs. 5.3%, respectively; all P > 0.05). CONCLUSIONS: This study suggests that diabetic patients with asymptomatic CAD have a higher cardiac mortality risk than those with symptomatic CAD, and that lack of revascularization therapy may be responsible for the poorer survival.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.subjectAgeden
dc.subjectCoronary Angiography/*methodsen
dc.subjectCoronary Artery Disease/*diagnosis/surgeryen
dc.subjectDiabetic Angiopathies/*diagnosis/surgeryen
dc.subjectFemaleen
dc.subjectFibrinolytic Agents/*therapeutic useen
dc.subjectFollow-Up Studiesen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMyocardial Infarction/*prevention & controlen
dc.subjectMyocardial Revascularization/*methods/mortalityen
dc.subjectPrognosisen
dc.titlePrognostic significance of asymptomatic coronary artery disease in patients with diabetes and need for early revascularization therapyen
dc.typeArticleen
dc.identifier.doi10.1111/j.1464-5491.2007.02182.x-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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