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Baseline peritoneal solute transport rate is not associated with markers of systemic inflammation or comorbidity in incident Korean peritoneal dialysis patients

Cited 21 time in Web of Science Cited 24 time in Scopus
Authors
Oh, Kook-Hwan; Moon, Ju-Young; Oh, Jieun; Kim, Seong Gyun; Hwang, Young-Hwan; Kim, Suhnggwon; Lee, Jung Sang; Ahn, Curie
Issue Date
2008-01-08
Publisher
Oxford University Press
Citation
Nephrol Dial Transplant. 2008 Jul;23(7):2356-64. Epub 2008 Jan 4.
Keywords
AdultBiological Markers/bloodBiological Transport/physiologyC-Reactive Protein/*metabolismDialysis Solutions/*pharmacokineticsFemaleGlucose/*pharmacokineticsHumansInflammation/*bloodInterleukin-6/*bloodKidney Failure, Chronic/blood/ethnology/therapyKoreaMaleMiddle Aged*Peritoneal DialysisProspective StudiesRegression AnalysisSerum Albumin/*metabolism
Abstract
BACKGROUND: It is controversial whether comorbid status or systemic inflammation has an influence on the peritoneal solute transport rate (PSTR). Our aim is to elucidate whether baseline PSTR is associated with markers of systemic inflammation or degree of comorbidity in incident peritoneal dialysis (PD) patients. METHODS: One hundred and ninety-five incident PD patients were prospectively included. Results of their baseline peritoneal equilibration test (PET) using 3.86% glucose PD fluid were analysed. Clinical and laboratory parameters of inflammation, comorbidity, nutritional status, dialysis adequacy and residual renal function (RRF) were assessed at the time of PET. RESULTS: Mean dialysate-to-plasma ratio for creatinine at 4 h (D/Pcr(4)) of our patients was 0.72 +/- 0.11. High-sensitivity C-reactive protein (hsCRP), serum interleukin-6 (IL-6) and serum albumin concentrations were closely interrelated to one another and these markers of systemic inflammation were also related to the Davies comorbidity score. No differences in age, sex ratio, body mass index, body surface area and presence of diabetes were found among four transport groups. RRF, total Kt/V, haemoglobin, nitrogen appearance and the Davies comorbidity score were not different either. High-sensitivity CRP, serum IL-6 and albumin concentrations were not associated with the baseline PSTR. By multiple linear regression analysis, only the serum albumin concentration measured at the time of PET (beta = -0.081 +/- 0.020, P < 0.001) remained significantly associated with D/Pcr(4). CONCLUSION: In our study with incident Korean PD patients, the baseline PSTR was not influenced by markers of systemic inflammation or comorbidity. For a subgroup of PD patients without serious comorbidity, other mechanisms of high baseline PSTR need to be elucidated.
ISSN
1460-2385 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18178604

http://hdl.handle.net/10371/22376
DOI
https://doi.org/10.1093/ndt/gfm921
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College of Medicine/School of Medicine (의과대학/대학원)Immunology (면역학전공)Journal Papers (저널논문_면역학전공)
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