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Increased laryngeal lavage lipid-laden macrophage index during acute bronchiolitis

Cited 4 time in Web of Science Cited 4 time in Scopus
Authors
Kim, C. K.; Kim, H. B.; Kurian, T.; Chung, J. Y.; Yoo, Y.; Koh, Y. Y.
Issue Date
2007-05-15
Publisher
Blackwell Publishing
Citation
Acta Paediatr. 2007 Jul;96(7):1025-9. Epub 2007 May 10.
Keywords
Acute DiseaseBiological Markers/metabolismBody Fluids/cytologyBronchiolitis, Viral/*complicationsFemaleGastroesophageal Reflux/complicationsHumansHydrogen-Ion ConcentrationInfantIrrigation*LaryngoscopyLarynxLipids/*analysisMacrophages, Alveolar/chemistry/*metabolismMaleNeutrophils/metabolismRespiratory Aspiration/*diagnosis/virologyRespiratory Syncytial Virus Infections/*complicationsSensitivity and Specificity
Abstract
AIM: To investigate aspiration risks associated with bronchiolitis in infants using the lipid-laden macrophage index (LLMI) from laryngeal lavages. METHODS: Laryngeal lavages from 29 infants with acute bronchiolitis caused by respiratory syncytial virus were evaluated (acute stage). Repeated studies were then performed at 3-4 weeks after the initial study (remission stage). Lavage cell counts and differentials were determined. The amount of lipid per single macrophage was evaluated and the LLMI was determined by evaluating 100 cells. In addition, 24-h pH monitoring (pHm) was performed in 16 patients. RESULTS: The LLMIs in the acute stage were significantly higher than those in the remission stage (p < 0.05). The neutrophil percentage of the laryngeal lavage correlated significantly with the LLMI (r = 0.707, p < 0.0001) during the acute stage of bronchiolitis. When patients were divided into pHm-positive (n = 5) and pHm-negative (n = 11) subgroups, a significant decrease in LLMI between acute and remission stages was noted among the pHm-positive (p < 0.01) subgroup, but not in the pHm-negative subgroup. CONCLUSION: These findings suggest that there is a transient increased LLMI in patients with bronchiolitis, which could be caused by gastroesophageal reflux.
ISSN
0803-5253 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17498191

http://hdl.handle.net/10371/22532
DOI
https://doi.org/10.1111/j.1651-2227.2007.00314.x
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College of Medicine/School of Medicine (의과대학/대학원)Immunology (면역학전공)Journal Papers (저널논문_면역학전공)
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