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Effects of purinergic stimulation on ciliary beat frequency and chloride secretion in sinusitis

Cited 4 time in Web of Science Cited 4 time in Scopus
Authors
Kim, I. S.; Rhee, C. S.; Lee, J. H.; Heo, J. H.; Park, J.; Lee, C. H.
Issue Date
2007-07-17
Publisher
Laryngoscope
Citation
Laryngoscope. 2007 Sep;117(9):1677-82.
Keywords
AnimalsChloride Channels/*metabolismCiliary Body/*metabolism*Mucociliary ClearanceNasal Mucosa/metabolism/ultrastructureRabbitsReceptors, Purinergic/*metabolismSinusitis/*metabolism/pathology
Abstract
OBJECTIVES: We aimed to identify the functional abnormality of sinusitis-affected mucosa by observing the responsiveness of the mucosa to purinergic stimulation after the onset of sinusitis and during the recovery period. We also aimed to identify possible beneficial effects of purinergic agonists on sinusitis. METHODS: A rabbit sinusitis model was developed by blocking maxillary ostia. Sinus mucosae were harvested immediately and 1 and 4 weeks after reopening the ostia. We measured chloride secretion and ciliary beat frequencies responding to purinergic stimulation. RESULTS: The increases of ciliary beat frequency by adenosine triphosphate (100 micromol/L) were 3.2%+/-8.5%, 7.9%+/-2.3%, and 12.2%+/-1.9% immediately after establishment of sinusitis and 1 week and 4 weeks after reopening of ostia, respectively. Chloride secretion stimulated by adenosine triphosphate also showed gradual increase during the recovery period. Grossly, the mucosae appeared to have normalized in 80% (4 of 5) after 4 weeks; however, functional and microscopic improvements were still incomplete. CONCLUSIONS: Mucosal functions, assessed by increase of ciliary activity and ion secretion by purinergic stimulation, and microscopic findings showed gradual but incomplete recovery after 4 weeks of recovery, in contrast to the gross normalization. Purinergic agonists may have beneficial effects on sinusitis by stimulating decreased ciliary motility and chloride secretion in sinusitis.
ISSN
0023-852X (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17632427

http://hdl.handle.net/10371/22534
DOI
https://doi.org/10.1097/MLG.0b013e31806911cc
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College of Medicine/School of Medicine (의과대학/대학원)Immunology (면역학전공)Journal Papers (저널논문_면역학전공)
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