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Multilocus analysis of atopy in Korean children using multifactor-dimensionality reduction

Cited 18 time in Web of Science Cited 18 time in Scopus
Authors
Park, H. W.; Shin, E. S.; Lee, J. E.; Kwon, H. S.; Chun, E.; Kim, S. S.; Chang, Y. S.; Kim, Y. K.; Min, K. U.; Kim, Y. Y.; Cho, S. H.
Issue Date
2006-11-24
Publisher
BMJ Publishing Group
Citation
Thorax. 2007 Mar;62(3):265-9. Epub 2006 Nov 22.
Keywords
AdolescentChildFemaleGene FrequencyGenotypeHumansHypersensitivity, Immediate/epidemiology/*geneticsKorea/epidemiologyMalePolymorphism, Single Nucleotide/*geneticsRegression AnalysisVascular Endothelial Growth Factor Receptor-2/*genetics
Abstract
BACKGROUND: Atopy is considered to be a complex genetic trait and does not follow a simple mendelian pattern of inheritance. It is now well recognised that gene-gene interactions are important in complex genetic disease. AIM: To analyse the influence of gene-gene interactions in the development of atopy. METHODS: A total of 2055 ethnically identical participants aged 10-18 years living in rural areas on Jeju Island, Korea, were randomly recruited. Atopy was defined as a positive skin prick test response to one or more common inhalant allergens. Gene-gene interactions among 12 polymorphic loci were analysed in the seven candidate genes of atopy using the multidimensionality-reduction method. RESULTS: A significant interaction was found between V297I in the gene coding vascular endothelial growth factor receptor 2 (KDR) and -308G-->A in the gene coding tumour necrosis factor (TNF)alpha on the risk of atopy, with a cross-validation consistency of 10 out of 10 and a prediction error of 35.9% (p = 0.001). Conventional logistic regression also revealed significant interactions between KDR and TNF for atopy. Individuals with the variant allele of -308G-->A in TNF (GA or AA) and V297I in KDR (VI or II) had a significantly higher risk of atopy (OR 2.23; 95% CI 1.48 to 3.57). CONCLUSION: KDR and TNF may synergistically influence the development of atopy through gene-gene interaction in Korean children and adolescents.
ISSN
0040-6376 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17121871

http://hdl.handle.net/10371/22556
DOI
https://doi.org/10.1136/thx.2006.065482
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College of Medicine/School of Medicine (의과대학/대학원)Immunology (면역학전공)Journal Papers (저널논문_면역학전공)
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