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Multilocus analysis of atopy in Korean children using multifactor-dimensionality reduction

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dc.contributor.authorPark, H. W.-
dc.contributor.authorShin, E. S.-
dc.contributor.authorLee, J. E.-
dc.contributor.authorKwon, H. S.-
dc.contributor.authorChun, E.-
dc.contributor.authorKim, S. S.-
dc.contributor.authorChang, Y. S.-
dc.contributor.authorKim, Y. K.-
dc.contributor.authorMin, K. U.-
dc.contributor.authorKim, Y. Y.-
dc.contributor.authorCho, S. H.-
dc.date.accessioned2009-12-24T10:02:38Z-
dc.date.available2009-12-24T10:02:38Z-
dc.date.issued2006-11-24-
dc.identifier.citationThorax. 2007 Mar;62(3):265-9. Epub 2006 Nov 22.en
dc.identifier.issn0040-6376 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17121871-
dc.identifier.urihttp://hdl.handle.net/10371/22556-
dc.description.abstractBACKGROUND: Atopy is considered to be a complex genetic trait and does not follow a simple mendelian pattern of inheritance. It is now well recognised that gene-gene interactions are important in complex genetic disease. AIM: To analyse the influence of gene-gene interactions in the development of atopy. METHODS: A total of 2055 ethnically identical participants aged 10-18 years living in rural areas on Jeju Island, Korea, were randomly recruited. Atopy was defined as a positive skin prick test response to one or more common inhalant allergens. Gene-gene interactions among 12 polymorphic loci were analysed in the seven candidate genes of atopy using the multidimensionality-reduction method. RESULTS: A significant interaction was found between V297I in the gene coding vascular endothelial growth factor receptor 2 (KDR) and -308G-->A in the gene coding tumour necrosis factor (TNF)alpha on the risk of atopy, with a cross-validation consistency of 10 out of 10 and a prediction error of 35.9% (p = 0.001). Conventional logistic regression also revealed significant interactions between KDR and TNF for atopy. Individuals with the variant allele of -308G-->A in TNF (GA or AA) and V297I in KDR (VI or II) had a significantly higher risk of atopy (OR 2.23; 95% CI 1.48 to 3.57). CONCLUSION: KDR and TNF may synergistically influence the development of atopy through gene-gene interaction in Korean children and adolescents.en
dc.language.isoen-
dc.publisherBMJ Publishing Groupen
dc.subjectAdolescenten
dc.subjectChilden
dc.subjectFemaleen
dc.subjectGene Frequencyen
dc.subjectGenotypeen
dc.subjectHumansen
dc.subjectHypersensitivity, Immediate/epidemiology/*geneticsen
dc.subjectKorea/epidemiologyen
dc.subjectMaleen
dc.subjectPolymorphism, Single Nucleotide/*geneticsen
dc.subjectRegression Analysisen
dc.subjectVascular Endothelial Growth Factor Receptor-2/*geneticsen
dc.titleMultilocus analysis of atopy in Korean children using multifactor-dimensionality reductionen
dc.typeArticleen
dc.contributor.AlternativeAuthor박흥우-
dc.contributor.AlternativeAuthor신은순-
dc.contributor.AlternativeAuthor이종은-
dc.contributor.AlternativeAuthor권혁수-
dc.contributor.AlternativeAuthor전은영-
dc.contributor.AlternativeAuthor김선신-
dc.contributor.AlternativeAuthor장윤석-
dc.contributor.AlternativeAuthor김윤근-
dc.contributor.AlternativeAuthor민경업-
dc.contributor.AlternativeAuthor김유영-
dc.contributor.AlternativeAuthor조상헌-
dc.identifier.doi10.1136/thx.2006.065482-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Immunology (면역학전공)Journal Papers (저널논문_면역학전공)
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