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Regulation of IL-18 expression by CRH in mouse microglial cells
Cited 24 time in
Web of Science
Cited 30 time in Scopus
- Authors
- Issue Date
- 2005-04-30
- Publisher
- Elsevier
- Citation
- Immunol Lett. 2005 May 15;98(2):291-6. Epub 2004 Dec 30.
- Keywords
- Animals ; Cells, Cultured ; Corticotropin-Releasing Hormone/*pharmacology ; Gene Expression Regulation/*drug effects ; Interferon-gamma/biosynthesis/secretion ; Interleukin-18/genetics/*metabolism ; Mice ; Mice, Inbred C57BL ; Microglia/*drug effects/*metabolism ; RNA, Messenger/genetics ; Reactive Oxygen Species/metabolism ; Receptors, Corticotropin-Releasing Hormone/genetics ; Signal Transduction/drug effects ; Titrimetry
- Abstract
- Corticotropin releasing hormone (CRH) is a major regulator of the stress response. This study examined whether CRH regulates interleukin-18 expression on microglia, BV2. Our data show that CRH enhanced IL-18 expression and significantly induced the secretion of functional IL-18 protein. Furthermore, CRH induced IL-18 production could be blocked by N-acetyl-L-cystein (NAC), which suggests that reactive oxygen intermediates (ROI) may be involved in regulating IL-18. Indeed, it was also found that CRH increased the generation of ROI. Taken together, these results indicate that CRH is an important mediator that regulates IL-18 expression in the brain during stress.
- ISSN
- 0165-2478 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15860230
https://hdl.handle.net/10371/22602
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