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Regulation of IL-18 expression by CRH in mouse microglial cells

Cited 22 time in Web of Science Cited 27 time in Scopus
Authors
Yang, Y.; Hahm, E.; Kim, Y.; Kang, J.; Lee, W.; Han, I.; Myung, P.; Kang, H.; Park, H.; Cho, D.
Issue Date
2005-04-30
Publisher
Elsevier
Citation
Immunol Lett. 2005 May 15;98(2):291-6. Epub 2004 Dec 30.
Keywords
AnimalsCells, CulturedCorticotropin-Releasing Hormone/*pharmacologyGene Expression Regulation/*drug effectsInterferon-gamma/biosynthesis/secretionInterleukin-18/genetics/*metabolismMiceMice, Inbred C57BLMicroglia/*drug effects/*metabolismRNA, Messenger/geneticsReactive Oxygen Species/metabolismReceptors, Corticotropin-Releasing Hormone/geneticsSignal Transduction/drug effectsTitrimetry
Abstract
Corticotropin releasing hormone (CRH) is a major regulator of the stress response. This study examined whether CRH regulates interleukin-18 expression on microglia, BV2. Our data show that CRH enhanced IL-18 expression and significantly induced the secretion of functional IL-18 protein. Furthermore, CRH induced IL-18 production could be blocked by N-acetyl-L-cystein (NAC), which suggests that reactive oxygen intermediates (ROI) may be involved in regulating IL-18. Indeed, it was also found that CRH increased the generation of ROI. Taken together, these results indicate that CRH is an important mediator that regulates IL-18 expression in the brain during stress.
ISSN
0165-2478 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15860230

http://hdl.handle.net/10371/22602
DOI
https://doi.org/10.1016/j.imlet.2004.12.003
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College of Medicine/School of Medicine (의과대학/대학원)Immunology (면역학전공)Journal Papers (저널논문_면역학전공)
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